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Profiles for ATP and Adenosine Release at the Carotid Body in Response to O2 Concentrations

  • SÍLVIA V. CONDE
  • EMÍLIA C. MONTEIRO
Part of the ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY book series (AEMB, volume 580)

Abstract

Excitatory effects on carotid body (CB) chemotransduction have been described for both adenosine and ATP. Adenosine when applied exogenously increases carotid sinus nerve (CSN) discharges in the cat, in vivo (McQueen and Ribeiro, 1983) and in vivo (Runold et al., 1990). Administration of adenosine and drugs that increase its endogenous levels stimulate ventilation in rats, an effect abolished by the section of CSN and mediated by A2 receptors (Monteiro and Ribeiro, 1987, 1989; Ribeiro and Monteiro, 1991). In humans, the intravenous infusion of adenosine causes hyperventilation and dyspnoea, an effect attributed to the activation of CB (Watt and Routledge, 1985, Watt et al., 1987; Maxwell et al., 1986; 1987, Uematsu et al., 2000). The excitatory effect of ATP at the CB described by Zhang et al. (2000) in co-cultures of type I cells with petrosal neurons was further supported by the finding that mice deficient in P2X2 showed a markedly attenuated ventilatory response to hypoxia (Rong et al., 2003) and by the detection of hypoxia- evoked ATP release from chemoreceptor cells of the rat carotid body (Buttigieg and Nurse, 2004).

Keywords

Carotid Body Extracellular Calcium Ventilatory Response Superior Cervical Ganglion Arterial Tissue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Acker, H. and Starlinger, H., 1984. Adenosine triphosphate content in the cat carotid body under different arterial O2 and CO2 conditions. Neurosci Lett., 50: 175–179.PubMedCrossRefGoogle Scholar
  2. Buttigieg, J. and Nurse, C.A., 2004. Detection of hypoxia-evoked ATP release from chemoreceptor cells of the rat carotid body. Biochem. Biophy. Res. Com., 322: 82–87.CrossRefGoogle Scholar
  3. Conde, S.V. and Monteiro, E.C., 2004. Hypoxia induces adenosine release from the rat carotid body. J. Neurochem., 89: 1148–1156.PubMedCrossRefGoogle Scholar
  4. Cunha RA, Almeida T and Ribeiro JA., 2001, Parallel modification of adenosine extracellular metabolism and modulatory action in the hippocampus of aged rats. J. Neurochem., 76: 372–382.PubMedCrossRefGoogle Scholar
  5. Maxwell D. L., Fuller R. W., Nolop K. B., Dixon C. M. S. and Hughes M. B. (1986) effects of adenosine on ventilatory responses to hypoxia and hypercapnia in humans. J. Appl. Physiol. 61: 1762–1766.PubMedGoogle Scholar
  6. Maxwell D. L., Fuller R. W., Conradson T-B., Dixon C. M. S., Aber V., Hughes M. B. and Barnes P. J. (1987) Contrasting effects of two xanthines, theophyline and enprofylline, on the cardio-respiratory stimulation of infused adenosine in man. Acta Physiol. Scand. 131: 459–465.PubMedCrossRefGoogle Scholar
  7. McQueen, D.S. and Ribeiro, J.A., 1983. On the specificity and type of receptor involved in carotid body chemoreceptor activation by adenosine in the cat. Br. J. Pharmacol., 80: 347–354.PubMedGoogle Scholar
  8. Monteiro, E.C. and Ribeiro, J.A., 1987. Ventilatory effects of adenosine mediated by carotid chemoreceptors in the rat. Naunyn-Schmiedeberg's Arch. Pharmacol., 335: 143–148.CrossRefGoogle Scholar
  9. Monteiro, B.C. and Ribeiro, J.A., 1989. Adenosine deaminase and adenosine uptake inhibitors facilitate ventilation in rats. Naunyn-Schmiedeberg's Arch. Pharmacol., 340: 230–238.CrossRefGoogle Scholar
  10. Obeso, A., Almaraz, L. and Gonzalez, C., 1986. Effects of 2-Deoxy-D-Glucose on In Vitro Cat Carotid Body. Brain Res., 371: 25–36PubMedCrossRefGoogle Scholar
  11. Ribeiro, J.A. and Monteiro, E.C., 1991. On the adenosine receptor involved in the excitatory action of adenosine on respiration: antagonist profile. Nucleosides Nucleotides, 10: 945–953.Google Scholar
  12. Rong, W., Gourine, A.V., Cockayne, D.A., Xiang, Z., Ford, A.P.D.W., Spyer, M. and Burnstock, G., 2003. Pivotal role of Nucleotide P2X2 receptor subunit of the ATP-gated ion channel mediating ventilatory responses to hypoxia, J. Neurosci., 23: 11315–11321.PubMedGoogle Scholar
  13. Runold, M., Cherniak, N.S. and Prabhakar, N.R., 1990. Effect of adenosine on isolated and superfused cat carotid body activity, Neurosci. Lett., 113: 111–114.PubMedCrossRefGoogle Scholar
  14. Uematsu T., Kozawa O., Matsuno H., Yoshikoshi H., Oh-uchi M., Kohno K., Nagashima S. and Kanamaru M. (2000) Pharmacokinetics and tolerability of intravenous infusion of adenosine (SUNY4001) in healthy volunteers. Br. J. Clin. Pharmacol. 50: 177–181.PubMedCrossRefGoogle Scholar
  15. Verna, A., Talib, N., Roumy, M. and Pradet, A., 1990. Effects of metabolic inhibitors and hypoxia on the ATP, ADP and AMP content of the rabbit carotid body in vitro: the metabolic hypothesis in question. Neurosci Lett., 116: 156–161.PubMedCrossRefGoogle Scholar
  16. Watt A. H., Reid P. G., Stephens M. R. and Routledge P. A. (1987) Adenosine –induced respiratory stimulation in man depends on site of infusion. Evidence for an action on the carotid body? Br. J. Clin. Pharmacol. 23: 486–490.PubMedGoogle Scholar
  17. Watt A. H. and Routledge P. A. (1985) adenosine stimulates respiration in man. Br. J. Clin. Pharmacol. 20: 503–506.PubMedGoogle Scholar
  18. Zhang, M., Zhong, H., Vollmer, C. and Nurse, C.A., 2000, Co-release of ATP and ACh mediates hypoxic signaling at rat carotid body chemoreceptors. J. Physiol., 525: 143–158.PubMedCrossRefGoogle Scholar

Copyright information

© Springer 2006

Authors and Affiliations

  • SÍLVIA V. CONDE
    • 1
  • EMÍLIA C. MONTEIRO
    • 1
  1. 1.Department of Pharmacology, Faculty of Medical SciencesNew University of LisbonLisbonPortugal

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