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Accumulation of Radiolabeled N-Oleoyl-Dopamine in the Rat Carotid Body

  • MIECZYSŁAW POKORSKI
  • DOMINIKA ZAJĄC
  • ANDRZEJ KAPUŚCIŃSKI
  • ZDZISŁAW MATYSIAK
  • ZBIGNIEW CZARNOCKI
Part of the ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY book series (AEMB, volume 580)

Abstract

Exogenously administered dopamine (DA) is liable to penetrate into the carotid body, which, as opposed to the brain, has no endothelial barrier. DA is stored in the secretory vesicles of chemoreceptor cells. The vesicles are reminiscent of micelle-like entities and the hydrophilic properties of DA molecules make it dubious that DA could be packed and stay sustained in such an environment. The possible problems with the intravesicular arrangement of DA molecules may be one reason for thecomplex, often erratic, and as yet not full well understood DA action in the chemosensing process. DA displays a spate of varying effects, from stimulation to inhibition, on carotid chemosensory discharge and ventilation, depending on the species, the dose, and the presynaptic or postsynaptic dopamine D2 receptor it interacts with (see for review Gonzales et al., 1994).

Keywords

Isotope Exchange Carotid Body Tritium Label Chemoreceptor Cell Intracarotid Injection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bisogno T., Melck D., Yu M., Bobrov M.Y., Gretskaya N.M., Bezuglov V.V., De Petrocellis L., Di Marzo V. N-acyl-dopamines: novel synthetic CB1 cannabinoid-receptor ligands and inhibitors of anandamide inactivation with cannabimimetic activity in vitro and in vivo. Biochem. J. 351: 817–824, 2000.PubMedCrossRefGoogle Scholar
  2. Chu C.J., Huang S.M., De Petrocellis L., Bisogno T., Ewing S.A., Miller J.D., Zipkin R.E., Daddario N., Appendino G., Di Marzo V., Walker J.M. N-oleoyl-dopamine, a novel endogenous capsaicin-like lipid that produces hyperalgesia. J. Biol. Chem. 278: 13633–13639, 2003.PubMedCrossRefGoogle Scholar
  3. Czarnocki Z., Matuszewska M.P., Matuszewska I. Highly efficient synthesis of fatty acid dopamides. Org. Prep. Proced. Int. 30: 699–702, 1998.CrossRefGoogle Scholar
  4. Donnelly D.F. Does catecholamine secretion mediate the hypoxia-induced increase in nerve activity? Biol. Signals 4: 304–309, 1995.PubMedGoogle Scholar
  5. Gonzalez C., Almaraz L., Obeso A., Rigual R. Oxygen and acid chemoreception in the carotid body chemoreceptors. Trends Neurosci. 15: 146–153, 1992.PubMedCrossRefGoogle Scholar
  6. Gonzalez C., Almaraz L., Obeso A., Rigual R. Carotid body chemoreceptors: from natural stimuli to sensory discharges. Physiol. Rev. 74: 829–898, 1994.PubMedGoogle Scholar
  7. Ide T., Shirahata M., Chou C.L., Fitzgerald R.S. Effects of a continuous infusion of dopamine on the ventilatory and carotid body responses to hypoxia in cats. Clin. Exp. Pharmacol. Physiol. 22: 658–664, 1995.PubMedGoogle Scholar
  8. Pokorski M., Matysiak Z. Fatty acid acylation of dopamine in the carotid body. Med. Hypoth. 50: 131–133, 1998.CrossRefGoogle Scholar
  9. Pokorski M., Matysiak Z., Marczak M. Ostrowski R.P., Kapuściński A., Matuszewska I., Kańska M., Czarnocki Z. Brain uptake of radiolabeled N-oleoyl-dopamine in the rat. Drug Dev. Res. 60: 217–224, 2003.CrossRefGoogle Scholar
  10. Pokorski M., Sakagami H., Kondo H. Classical protein kinase C and its hypoxic stimulus-induced translocation in the cat and rat carotid body. Eur. Respir. J. 16: 459–463, 2000.PubMedCrossRefGoogle Scholar

Copyright information

© Springer 2006

Authors and Affiliations

  • MIECZYSŁAW POKORSKI
    • 1
  • DOMINIKA ZAJĄC
    • 1
  • ANDRZEJ KAPUŚCIŃSKI
    • 1
  • ZDZISŁAW MATYSIAK
    • 2
  • ZBIGNIEW CZARNOCKI
    • 3
  1. 1.Medical Research CenterPolish Academy of SciencesWarsaw
  2. 2.Institute of Biochemistry and BiophysicsPolish Academy of SciencesWarsaw
  3. 3.Faculty of ChemistryWarsaw UniversityWarsawPoland

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