Accumulation of Radiolabeled N-Oleoyl-Dopamine in the Rat Carotid Body
Exogenously administered dopamine (DA) is liable to penetrate into the carotid body, which, as opposed to the brain, has no endothelial barrier. DA is stored in the secretory vesicles of chemoreceptor cells. The vesicles are reminiscent of micelle-like entities and the hydrophilic properties of DA molecules make it dubious that DA could be packed and stay sustained in such an environment. The possible problems with the intravesicular arrangement of DA molecules may be one reason for thecomplex, often erratic, and as yet not full well understood DA action in the chemosensing process. DA displays a spate of varying effects, from stimulation to inhibition, on carotid chemosensory discharge and ventilation, depending on the species, the dose, and the presynaptic or postsynaptic dopamine D2 receptor it interacts with (see for review Gonzales et al., 1994).
KeywordsIsotope Exchange Carotid Body Tritium Label Chemoreceptor Cell Intracarotid Injection
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