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A Comparative Study of the Hypoxic Secretory Response between Neonatal Adrenal Medulla and Adult Carotid Body from the Rat

  • A.J. RICO
  • S.P. FERNANDEZ
  • J. PRIETO-LLORET
  • A. GOMEZNIÑO
  • C. GONZALEZ
  • R. RIGUAL
Part of the ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY book series (AEMB, volume 580)

Abstract

Perinatal adrenal medulla responds to hypoxia by increasing the release of catecholamine (CA) that are responsible for metabolic, cardio-circulatory and respiratory mechanisms crucial to the adaptation to the extrauterine life (3, 11). In neonatal rat, hypoxia elicits directly this secretory response since splachnic innervation of AM is not mature until the second week of postnatal life (10).

Keywords

Chromaffin Cell Carotid Body Carbon Fiber Electrode Chemoreceptor Cell Extrauterine Life 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Gonzalez, C., Almaraz, L., Obeso, A., and Rigual, R. Oxygen and acid chemoreception in the carotid body chemoreceptors. Trends Neurosci. 15: 146–53, 1992.PubMedCrossRefGoogle Scholar
  2. 2.
    Gonzalez, C., Almaraz, L., Obeso, A. and Rigual, R. Carotid body chemoreceptors: from natural stimuli to sensory discharges. Phsiol. Rev. 74: 829–898, 1994.Google Scholar
  3. 3.
    Lagercrantz, H., and Slotkin, T.A. The “stress” of being born. Sci. Am. 254: 100–107, 1986.PubMedCrossRefGoogle Scholar
  4. 4.
    Lopez-Lopez, J.R., and Peers, C. Electrical Properties of chemoreceptor cells. In: The carotid body chemoreceptors, (C. Gonzalez eds) Springer-Verlag, NY, 1997, pp. 41–78.Google Scholar
  5. 5.
    Mochizuki-Oda, N., Takeuchi, Y., Matsumura, K., Oosawa, Y., and Watanabe, Y. Hypoxia-Induced catecholamine release and intracellular Ca2+increase via supression of K+ channels in cultured rat adrenal chromaffin cells. J. Neurochem. 69: 377–387, 1997.PubMedCrossRefGoogle Scholar
  6. 6.
    Perez-Garcia, M.T., Almaraz, L., and Gonzalez, C. Cyclic AMP modulates differentially the release of dopamine induced by hypoxia and other stimuli and increases dopamine synthesis in the rabbit carotid body. J. Neurochem. 57: 1992–2000, 1991.PubMedCrossRefGoogle Scholar
  7. 7.
    Prakriya, M., and Lingle, C.J. BK channel activation by brief depolarizations requires Ca2+ channels in rat chromaffin cells. J. Neurophysiol. 81: 2267–2278, 1999.PubMedGoogle Scholar
  8. 8.
    Rigual. R., Almaraz L., Gonzalez C., and Donnelly, D.F. Developmental changes in chemoreceptor nerve activity and catecholamine secretion in rabbit cartodid body: posible role of Na+ and Ca2+ currents. Plugers Arch. 439: 463–470, 2000.CrossRefGoogle Scholar
  9. 9.
    Rigual, R., Montero, M., Rico, A.J., Prieto-Lloret, J., Alonso, M.T., and Alvarez, J. Modulation of secretion by the endoplasmic reticulum in mouse chromaffin cells. Eur. J. Neurosci. 167: 1690–1696, 2002.CrossRefGoogle Scholar
  10. 10.
    Seidler, F.J., and Slotkin, T.A. Adrenomedullary function in the neonatal rat: response to acute hypoxia. J. Physiol. 358: 1–16, 1985.PubMedGoogle Scholar
  11. 11.
    Slotkin, T.A., and Seidler, F.G. Adrenomedullary catecholamine release in the fetus and newborn: secretory mechanisms and their role in stress and survival. J. Dev. Physiol. 10: 1–16, 1988.PubMedGoogle Scholar
  12. 12.
    Thompson, R.J., Jackson, A., and Nurse, C.A. Developmental loss of hypoxic chemosensitivity in rat adrenomedullary chromaffin cells. J. Physiol. 498: 503–510, 1997.PubMedGoogle Scholar
  13. 13.
    Vicario, I., Rigual, R., Obeso, A., and Gonzalez, C. Characterization of the synthesis and release of catecholamine in the rat carotid body in vitro. Am. J. Physiol. Cell Physiol. 278: 490–499, 2000.Google Scholar

Copyright information

© Springer 2006

Authors and Affiliations

  • A.J. RICO
    • 1
  • S.P. FERNANDEZ
    • 1
  • J. PRIETO-LLORET
    • 1
  • A. GOMEZNIÑO
    • 1
  • C. GONZALEZ
    • 1
  • R. RIGUAL
    • 1
  1. 1.Departamento de Bioquímica y Biología Molecular y Fisiología /(IBGM)Universidad de Valladolid /(CSIC). Facultad de Medicina. Universidad de ValladolidValladolidSpain

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