Carotid Body Volume in Three-Weeks-Old Rats Having an Episode of Neonatal Anoxia



The development of oxygen chemosensitivity in carotid chemoreceptor cells, i.e. type I cell (glomus cell), is reported to continue postnatally (Wasicko et al., 1999), and it has been suggested that environmental experiences such as episode of hypoxia and chronic hypoxia during critical period of maturation may result in long-term alterations in the structure or function of the respiratory control neural network (Carroll, 2003). In the previous studies, we have observed no apparent effect on the hypoxic ventilatory response (HVR) in the day 7 newborn rats, which had daily episode of anoxia from day 1 to day 6 (day 0 = day of birth) (Saiki and Mortola, 1994), but significantly higher HVR in the 3-weeks-old rats, which had an episode of anoxia on day 3-4 after birth (Saiki and Matsumoto, 1999). These results suggest that the severity of anoxia and the timing of the anoxic episode as well as the assessment of HVR may be important factors, and that an episode of anoxia during the neonatal period has long-lasting effects on the control of ventilation in rats. Because no further information is available on the effects, including carotid body chemoreceptors, we examined whether or not an episode of anoxia in neonatal period induces changes in the carotid body and glomus cell structures in the three-weeks-old rats.


Neonatal Period Carotid Body Intermittent Hypoxia Ventilatory Control Mechanism Chronic Intermittent Hypoxia 
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© Springer 2006

Authors and Affiliations

    • 1
    • 2
    • 1
  1. 1.Department of Physiology, School of Dentistry at TokyoNippon Dental UniversityTokyoJapan
  2. 2.Department of Pediatric Dentistry, School of Dentistry at TokyoNippon Dental UniversityTokyoJapan

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