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Carotid Body Volume in Three-Weeks-Old Rats Having an Episode of Neonatal Anoxia

  • CHIKAKO SAIKI
  • MASAYA MAKINO
  • SHIGEJI MATSUMOTO
Part of the ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY book series (AEMB, volume 580)

Abstract

The development of oxygen chemosensitivity in carotid chemoreceptor cells, i.e. type I cell (glomus cell), is reported to continue postnatally (Wasicko et al., 1999), and it has been suggested that environmental experiences such as episode of hypoxia and chronic hypoxia during critical period of maturation may result in long-term alterations in the structure or function of the respiratory control neural network (Carroll, 2003). In the previous studies, we have observed no apparent effect on the hypoxic ventilatory response (HVR) in the day 7 newborn rats, which had daily episode of anoxia from day 1 to day 6 (day 0 = day of birth) (Saiki and Mortola, 1994), but significantly higher HVR in the 3-weeks-old rats, which had an episode of anoxia on day 3-4 after birth (Saiki and Matsumoto, 1999). These results suggest that the severity of anoxia and the timing of the anoxic episode as well as the assessment of HVR may be important factors, and that an episode of anoxia during the neonatal period has long-lasting effects on the control of ventilation in rats. Because no further information is available on the effects, including carotid body chemoreceptors, we examined whether or not an episode of anoxia in neonatal period induces changes in the carotid body and glomus cell structures in the three-weeks-old rats.

Keywords

Neonatal Period Carotid Body Intermittent Hypoxia Ventilatory Control Mechanism Chronic Intermittent Hypoxia 
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References

  1. Carroll J.L. Plasticity in respiratory motor control. Invited Review: Developmental plasticity in respiratory control. J Appl Physiol 2003; 94: 375–389.PubMedCrossRefGoogle Scholar
  2. Erickson J.T., Mayer C., Jawa A., Ling L., Olson E.B., Vidruk E.H., Mitchell G.S., Katz D.M. Chemoafferent degeneration and carotid body hypoplasia following chronic hyperoxia in newborn rats. J Physiol 1998; 509: 519–526.PubMedCrossRefGoogle Scholar
  3. Kent C., Rowe H.L. The immunolocalisation of ubiquitin carboxyl-terminal hydrolase (PGP9.5) in developing paraneurons in the rat. Dev Brain Res 1992; 68: 241–246.CrossRefGoogle Scholar
  4. Kusakabe T., Hayashida Y., Matsuda H., Gono Y., Powell F.L., Ellisman M.H., Kawakami T., Takenaka T. Hypoxic adaptation of the peptidergic innervation in the rat carotid body. Brain Res 1998; 806: 165–174.PubMedCrossRefGoogle Scholar
  5. Okubo S, Mortola, J.P. long-term respiratory effects of neonatal hypoxia in the rat. J Appl Physiol 1988; 64: 952–958.PubMedCrossRefGoogle Scholar
  6. Okubo S, Mortola, J.P. Control of ventilation in adult rats hypoxic in the neonatal period. Am J Physiol 1990; 259: R836–R841.PubMedGoogle Scholar
  7. Peng Y-J., Overholt J.L., Kline D., Kumar G.K., Prabhakar N.R. Induction of sensory long-term facilitation in the carotid body by intermittent hypoxia: implications for recurrent apneas. PNAS 2003; 100: 10073–10078.PubMedCrossRefGoogle Scholar
  8. Peng Y-J., Rennison J., Prabhakar N.R. Intermittent hypoxia augments carotid body and ventilatory response to hypoxia in neonatal pups. J Appl Physiol 2004; 97: 2020–2025.PubMedCrossRefGoogle Scholar
  9. Saiki C., Matsumoto S. Effect of neonatal anoxia on the ventilatory response to hypoxia in developing rats. Pediatr Pulmonol 1999; 28: 313–320.PubMedCrossRefGoogle Scholar
  10. Saiki C., Mortola J.P. Ventilatory control in infant rats after daily episodes of anoxia. Pediatr Res 1994; 35: 490–493.PubMedGoogle Scholar
  11. Wasicko M.J., Sterni L.M., Bamford O.S., Montrose M.H., Carroll, J.L. Resetting and postnatal maturation of oxygen chemosensitivity in rat carotid chemoreceptor cells. J Physiol 1999; 514: 493–503.PubMedCrossRefGoogle Scholar

Copyright information

© Springer 2006

Authors and Affiliations

  • CHIKAKO SAIKI
    • 1
  • MASAYA MAKINO
    • 2
  • SHIGEJI MATSUMOTO
    • 1
  1. 1.Department of Physiology, School of Dentistry at TokyoNippon Dental UniversityTokyoJapan
  2. 2.Department of Pediatric Dentistry, School of Dentistry at TokyoNippon Dental UniversityTokyoJapan

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