The Effect of Hyperoxia on Reactive Oxygen Species (ROS) in Petrosal and Nodose Ganglion Neurons during Development (Using Organotypic Slices)

  • D. J. KWAK
  • S. D. KWAK
  • E. B. GAUDA


Peripheral arterial chemoreceptors, within the carotid body (CB), are critical in maintaining respiratory and cardiac hemostasis by uniquely sensing changes in O2 tension. The components of the peripheral arterial chemoreceptors are found within the CB, but the physiologic effects of activation of these chemoreceptors are widespread and significant (Gonzalez et al., 1994). The CB is located in the bifurcation of the carotid artery and consists of three major neuronal components that include: 1) type I chemosensory cells, also known as glomus cells, which contain neurotransmitters and autoreceptors; 2) type II cells, which are similar to supportive glial cells; and 3) chemoafferent nerve fibers from the carotid sinus nerve, a branch of the IX cranial nerve, with cell bodies in the petrosal ganglion (PG) (Verna 1997).


Carotid Body Glomus Cell Peripheral Chemoreceptor Hyperoxic Exposure Carotid Sinus Nerve 
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Copyright information

© Springer 2006

Authors and Affiliations

  • D. J. KWAK
    • 1
  • S. D. KWAK
    • 1
  • E. B. GAUDA
    • 1
  1. 1.Department of PediatricsJohns Hopkins University School of MedicineBaltimoreUSA

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