Genetic Regulation of Chemoreceptor Development in DBA/2J and A/J Strains of Mice
The role of the carotid body (CB) in response to hypoxia is very well defined (Fitzgerald and Shirahata, 1997). The hypoxic ventilatory response (HVR) is characterized by an increase in ventilation, but this response remains variable among individuals (Eisele et al., 1992; Vizek et al., 1987; Weil 1970). Genetics may play a critical role in explaining this variability. Indeed, longitudinal and twin studies do demonstrate the role of genetics in the HVR (Collins et al., 1978; Kawakami et al., 1982). Studies utilizing inbred strains of mice have also demonstrated the effect of genetics on the response to hypoxia (Tankersley et al., 1994 & 2000). Two strains of mice in these studies were identified as having extreme responses to hypoxia.
KeywordsTyrosine Hydroxylase Inbred Strain Carotid Body Positive Ratio Glomus Cell
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