Dual Origins of the Mouse Carotid Body Revealed by Targeted Disruption of Hoxa3 and Mash1
The carotid body is the main arterial chemoreceptor that senses oxygen levels in the blood. In mammalian species, the carotid body is localized in the carotid bifurcation and innervated by the carotid sinus nerve consisting of sensory fibers from the glossopharyngeal nerve. The organ also receives the ganglioglomerular nerve issuing from the superior cervical ganglion of sympathetic trunk (Verna, 1979). In the mouse, especially, the carotid body joins with the superior cervical ganglion and is penetrated by nerve bundles derived from the ganglion (Kameda et al., 2002). In contrast to mammalian species, the carotid body of chickens is situated in the cervico-thoracic region together with the thyroid, parathyroid and ultimobranchial glands, which form a continuous series along the common carotid artery. The organ is located between the distal (nodose) ganglion of the vagus nerve and the recurrent laryngeal nerve and supplied richly with their branches (see Kameda, 2002 for references).
KeywordsNeural Crest Common Carotid Artery Neural Crest Cell Carotid Body Superior Cervical Ganglion
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