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Localization of Ca/Calmodulin-Dependent Protein Kinase I in the Carotid Body Chief Cells and the Ganglionic Small Intensely Fluorescent (SIF) Cells of Adult Rats

  • HISAE HOSHI
  • HIROYUKI SAKAGAMI
  • YUJI OWADA
  • HISATAKE KONDO
Part of the ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY book series (AEMB, volume 580)

Abstract

Control of cellular functions by extracellular signal-induced elevation of intracellular Ca is a common theme in excitable biosystems including the carotid body chemoreception. The Ca-signal is delivered to appropriate intracellular target proteins via phosphorylation catalyzed by multifunctional Ca/calmodulindependent protein kinases (CaM kinases), which are composed of types I, II and IV (Hanson and Schulman, 1992; Sakagami and Kondo, 1998). In order to see how CaM kinases are involved in the chemoreception, the present study examined the localization of CaM kinase I in immuno-light and electron microscopy in the rat carotid body as well as its adjacent superior cervical ganglion. The latter contains SIF (small intensely fluorescent) cells, at least some of which exhibit cytological features including the innervation similar to those of the carotid body chief cells (Kondo, 1977).

Keywords

Carotid Body Superior Cervical Ganglion Chief Cell Sustentacular Cell Immunoreactive Material 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer 2006

Authors and Affiliations

  • HISAE HOSHI
    • 1
  • HIROYUKI SAKAGAMI
    • 1
  • YUJI OWADA
    • 1
  • HISATAKE KONDO
    • 1
  1. 1.Division of Histology, Department of Cell Biology, Graduate School of MedicineTohoku UniversitySendaiJAPAN

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