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Nature’s Versatile Engine: Insect Flight Muscle Inside and Out pp 2–15Cite as

The Contributions of Genetics to the Study of Insect Flight Muscle Function

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Part of the book series: Molecular Biology Intelligence Unit ((MBIU))

Abstract

The utility of Drosophila as a model genetic organism has had a profound impact upon our understanding of muscle assembly and function. This has arisen from the large number of mutant alleles that have been isolated and characterized using a variety of screens, and also reflects an highly efficient method for generating transgenic animals. Combining these two methodologies has permitted genetic rescue experiments using both wild-type and engineered alleles, to probe precisely the functions of proteins or their domains in myofibril assembly and contractility. Genetical approaches using suppressor screens are now being used to more precisely determine protein function in the myofibril. In this review I shall summarize how these approaches have been informative in understanding muscle formation and function, and discuss how Drosophila genetics will serve the muscle field in the future.

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  1. Department of Biology, University of New Mexico, Albuquerque, New Mexico, USA

    Richard M. Cripps

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Cripps, R.M. (2006). The Contributions of Genetics to the Study of Insect Flight Muscle Function. In: Nature’s Versatile Engine: Insect Flight Muscle Inside and Out. Molecular Biology Intelligence Unit. Springer, Boston, MA. https://doi.org/10.1007/0-387-31213-7_1

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