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The Three-Dimensional Structure of p53

  • Chapter
The p53 Tumor Suppressor Pathway and Cancer

Part of the book series: Protein Reviews ((PRON,volume 2))

Abstract

The p53 tumor suppressor is one of the best studied human proteins. As described in this chapter, significant progress has been made towards understanding its three-dimensional structure. The structural information has helped our understanding of p53 function and regulation and has also explained how tumor-associated mutations inactivate p53. The challenge now is to extend the structural studies to visualize multidomain fragments of p53 and even full-length p53. Structures of p53 with important partner molecules, such as transcriptional coactivators, are also needed. In the end the structural information is likely to form the basis for pharmacologic rescue of p53 function in human cancer.

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Authors and Affiliations

  1. Wistar Institute, Philadelphia, PA, 19104-4268

    Elena S. Stavridi, Yentram Huyen, Emily A. Sheston & Thanos D. Halazonetis

  2. Graduate Group in Biomedical Sciences, USA

    Yentram Huyen

  3. Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, 19104

    Thanos D. Halazonetis

Authors
  1. Elena S. Stavridi
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  2. Yentram Huyen
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  3. Emily A. Sheston
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  4. Thanos D. Halazonetis
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Editors and Affiliations

  1. St. Jude Children’s Research Hospital, Memphis, Tennessee

    Gerard P. Zambetti

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Stavridi, E.S., Huyen, Y., Sheston, E.A., Halazonetis, T.D. (2005). The Three-Dimensional Structure of p53. In: Zambetti, G.P. (eds) The p53 Tumor Suppressor Pathway and Cancer. Protein Reviews, vol 2. Springer, Boston, MA. https://doi.org/10.1007/0-387-30127-5_2

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