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The p53 Tumor Suppressor Pathway and Cancer pp 1–23Cite as

The p53 Network

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Part of the book series: Protein Reviews ((PRON,volume 2))

Abstract

Cancer arises through a series of mutations in selected oncogenes, tumor suppressor genes, or genes involved in DNA repair or replication. The tumor suppressor gene products frequently monitor the efficiency of cellular duplication by populating checkpoints in the process of cell division. When defective, the tumor suppressor genes can lead to inherited predispositions in the development of cancers. Almost every human cancer contains mutations in the tumor suppressor pathways of p53, retinoblastoma (Rb), or both. Each of these pathways receives a complex set of signals and reports from the extracellular and intracellular environments of a cell and in response regulate “go-no go” decisions in the cell cycle. This chapter will review some of the origins of research into the p53 gene and its protein. This will form a basis for understanding the other chapters of this book and provide a foundation upon which new facts are built. It also points to important future directions for this field.

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Authors and Affiliations

  1. Institute for Advanced Study, Einstein Drive, Princeton, NJ, 08540

    Arnold J. Levine

  2. The Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, NJ, 08903

    Arnold J. Levine, Gareth L. Bond, Angelica K. Teresky & Shengkan Jin

  3. Department of Biological Sciences, Hunter College, 695 Park Avenue, New York, NY, 10021

    Jill Bargonetti

  4. Department of Epidemiology / Public Health, Yale University, New Haven, CT, 06520

    Josephine Hoh

  5. Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, 10021

    Kenan Onel

  6. Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA, 02115

    Michael Overholtzer

  7. Rockefeller University, 1230 York Avenue, New York, NY, 10021

    Archontoula Stoffel & Christine A. Walsh

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  1. St. Jude Children’s Research Hospital, Memphis, Tennessee

    Gerard P. Zambetti

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© 2005 Springer Science Business Media, Inc.

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Levine, A.J. et al. (2005). The p53 Network. In: Zambetti, G.P. (eds) The p53 Tumor Suppressor Pathway and Cancer. Protein Reviews, vol 2. Springer, Boston, MA. https://doi.org/10.1007/0-387-30127-5_1

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