Abstract
The Beta-Blocker Heart Attack Trial (BHAT) compared the beta-blocker propranolol against placebo in 3,837 people who had recently had a myocardial infarction. The primary outcome was total mortality. The trial ended nine months ahead of schedule because of clear benefit from propranolol. The independent monitoring committee considered several newly developed statistical approaches in recommending early stopping, as well as other factors, including what had been communicated in the consent form to the participants.
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© 2006 Springer Science+Business Media, Inc.
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Friedman, L.M., DeMets, D.L., Hardy, R. (2006). Data and Safety Monitoring in the Beta-Blocker Heart Attack Trial: Early Experience in Formal Monitoring Methods. In: DeMets, D.L., Furberg, C.D., Friedman, L.M. (eds) Data Monitoring in Clinical Trials. Springer, New York, NY. https://doi.org/10.1007/0-387-30107-0_6
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DOI: https://doi.org/10.1007/0-387-30107-0_6
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