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Oxygen Transport to Tissue XXVII pp 17–22Cite as

O2 Uptake Kinetics in Skeletal Muscle: Why is it so Slow? And What Does it Mean?

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Part of the book series: Advances in Experimental Medicine and Biology ((volume 578))

5. Conclusions

The rate at which skeletal muscle oxidative phosphorylation adjusts to a new metabolic requirement (“VO2 kinetics”) is one of the determinants of exercise tolerance. The VO2 kinetics does not seem to depend, in normal conditions, on O2 availability, at least for moderate-intensity exercise. A relatively minor limiting factor for the VO2 kinetics could be the inhibition of mitochondrial respiration by NO. PCr hydrolysis can be considered not only an energy buffer for ATP resynthesis early during the metabolic transition, but also one of the main controllers of oxidative phosphorylation.

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Author information

Authors and Affiliations

  1. Dipartimento di Scienze e Tecnologie Biomediche, Università degli Studi di Milano, I-20090, Segrate, (MI), Italy

    Bruno Grassi

Authors
  1. Bruno Grassi
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Editor information

Editors and Affiliations

  1. C.E.M.O.T.—Centro Interdipantimentale di Ricerca in Emoreologia, Microcircolazione, Transporto di Ossigeno e Tecnologie Ottiche non Invasive, Università di Bari, Bari, Italy, 70124

    Giuseppe Cicco

  2. College of Engineering, University of Maryland Baltimore County, Baltimore, MD, 21250, USA

    Duane F. Bruley

  3. Dip. Di Scienze e Tecnologie Biomediche, Università de L’Aquila, L’Aquila, Italy, 67100

    Marco Ferrari

  4. Regional Medical Physics Department, University Hospital of North Durham, Durham, UK, DH1 5TW

    David K. Harrison

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Grassi, B. (2006). O2 Uptake Kinetics in Skeletal Muscle: Why is it so Slow? And What Does it Mean?. In: Cicco, G., Bruley, D.F., Ferrari, M., Harrison, D.K. (eds) Oxygen Transport to Tissue XXVII. Advances in Experimental Medicine and Biology, vol 578. Springer, Boston, MA . https://doi.org/10.1007/0-387-29540-2_3

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