4. Summary
During conditions with experimental diabetes mellitus, it is evident that several alterations in renal oxygen metabolism occur, including increased mitochondrial respiration and increased lactate accumulation in the renal tissue. Consequently, these alterations will contribute to decrease the interstitial pO2, preferentially in the renal medulla of animals with sustained long-term hyperglycemia.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
6. References
J. J. Cohen, and D. E. Kamm, Renal metabolism: Relation to renal function., in: The Kidney, edited by M. B. Brenner, and F. C. Rector (W.B. Saunders, Philadelphia, 1981), pp. 144–248.
S. Klahr, and M. Hammarman, Renal metabolism, in: The Kidney: Physiology and Pathophysiology, edited by D. W. Seldin, and G. Giebisch (Raven Press, New York, 1985), pp. 699–718.
K. Aukland, and J. Krog, Renal oxygen tension, Nature 188, 671 (1960).
M. N. Levy, and E. S. Imperial, Oxygen shunting in renal cortical and medullary capillaries, Am J Physiol 200, 159–162 (1961).
K. Aukland, Studies on Intrarenal Circulation with Special Reference to Gas Exchange, J Oslo City Hosp 14, 115–46 (1964).
The Diabetes Control and Complications Trail Research Group, The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus., N Engl J Med 329, 977–86. (1993).
M. Brezis, S. Rosen, P. Silva, and F. H. Epstein, Renal ischemia: a new perspective, Kidney Int 26, 375–383 (1984).
M. Brezis, and S. Rosen, Hypoxia of the renal medulla-its implication for disease, New Engl J Med 332, 647–655 (1995).
G. Pugliese, R. G. Tilton, and J. R. Williamson, Glucose-induced metabolic imbalances in the pathogenesis of diabetic vascular disease, Diabetes Metab Rev 7, 35–59. (1991).
P. J. Dyck, A. Windebank, H. Yasuda, F. J. Service, R. Rizza, and B. Zimmerman, Diabetic neuropathy, Adv Exp Med Biol 189, 305–320 (1985).
M. J. Stevens, J. Dananberg, E. L. Feldman, S. A. Lattimer, M. Kamijo, T. P. Thomas, H. Shindo, A. A. Sima, and D. A. Greene, The linked roles of nitric oxide, aldose reductase and, (Na+, K+)-ATPase in the slowing of nerve conduction in the streptozotocin diabetic rat, J Clin Invest 94, 853–859 (1994).
M. K. Van den Enden, J. R. Nyengaard, E. Ostrow, J. H. Burgan, and J. R. Williamson, Elevated glucose levels increase retinal glycolysis and sorbitol pathway metabolism. Implications for diabetic retinopathy, Invest Ophthalmol Vis Sci 36, 1675–85 (1995).
F. Palm, P. Hansell, G. Ronquist, A. Waldenstrom, P. Liss, and P. O. Carlsson, Polyol-pathway-dependent disturbances in renal medullary metabolism in experimental insulin-deficient diabetes mellitus in rats, Diabetologia 47, 1223–31 (2004).
R. G. Tilton, L. D. Baier, J. E. Harlow, S. R. Smith, E. Ostrow, and J. R. Williamson, Diabetes-induced glomerular dysfunction: links to a more reduced cytosolic ratio of NADH/NAD+, Kidney Int 41, 778–788 (1992).
J. R. Williamson, K. Chang, M. Frangos, K. S. Hasan, Y. Ido, T. Kawamura, J. R. Nyengaard, M. van den Enden, C. Kilo, and R. G. Tilton, Hyperglycemic pseudohypoxia and diabetic complications, Diabetes 42, 801–813 (1993).
R. I. Dorin, V. O. Shah, D. L. Kaplan, B. S. Vela, and P. G. Zager, Regulation of aldose reductase gene expression in renal cortex and medulla of rats, Diabetologia 38, 46–54 (1995).
T. Nishikawa, D. Edelstein, X. L. Du, S. Yamagishi, T. Matsumura, Y. Kaneda, M. A. Yorek, D. Beebe, P. J. Oates, H. P. Hammes, I. Giardino, and M. Brownlee, Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage, Nature 404, 787–790 (2000).
F. Palm, J. Cederberg, P. Hansell, P. Liss, and P. O. Carlsson, Reactive oxygen species cause diabetesinduced decrease in renal oxygen tension, Diabetologia 46, 1153–1160 (2003).
A. Koivisto, A. Matthias, G. Bronnikov, and J. Nedergaard, Kinetics of the inhibition of mitochondrial respiration by NO, FEBS Letters 417, 75–80 (1997).
A. Koivisto, J. Pittner, M. Froelich, and A. E. Persson, Oxygen-dependent inhibition of respiration in isolated renal tubules by nitric oxide, Kidney Int 55, 2368–2375 (1999).
C. G. Schnackenberg, Physiological and pathophysiological roles of oxygen radicals in the renal microvasculature, Am J Physiol Regul Integr Comp Physiol 282, R335–R342 (2002).
C. E. Mogensen, Glomerular filtration rate and renal plasma flow in normal and diabetic man during elevation of blood sugar levels, Scand J Clin Lab Invest 28, 177–82 (1971).
F. Palm, P. Liss, A. Fasching, P. Hansell, and P. O. Carlsson, Transient glomerular hyperfiltration in the streptozotocin-diabetic Wistar Furth rat, Ups J Med Sci 106, 175–182 (2001).
M. P. O’Donnell, B. L. Kasiske, and W. F. Keane, Glomerular hemodynamic and structural alterations in experimental diabetes mellitus, Faseb J 2, 2339–2347 (1988).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2006 Springer Science+Business Media, Inc.
About this paper
Cite this paper
Palm, F., Carlsson, PO., Fasching, A., Hansell, P., Liss, P. (2006). Diabetes-Induced Decrease in Renal Oxygen Tension: Effects of an Altered Metabolism. In: Cicco, G., Bruley, D.F., Ferrari, M., Harrison, D.K. (eds) Oxygen Transport to Tissue XXVII. Advances in Experimental Medicine and Biology, vol 578. Springer, Boston, MA . https://doi.org/10.1007/0-387-29540-2_26
Download citation
DOI: https://doi.org/10.1007/0-387-29540-2_26
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-387-29543-5
Online ISBN: 978-0-387-29540-4
eBook Packages: Physics and AstronomyPhysics and Astronomy (R0)