Abstract
All vertebrate genomes are heavily methylated at CpG dinucleotide sites, and methylated CpG dinucleotides are prone to CpG→TpG mutations through spontaneous deamination. This leaves different footprints on coding and non-coding sequences. We capture these different fingerprints by five indices that can be used to discriminate between coding and non-coding (intron) sequences. We also show that a linear discriminant function derived from a training set of coding and intron sequences from human chromosome 22 can be successfully used in gene-finding of the zebrafish genome.
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© 2006 Springer Science+Business Media, Inc.
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Xia, X. (2006). Content Sensors Based on Codon Structure and DNA Methylation for Gene Finding in Vertebrate Genomes. In: Kolchanov, N., Hofestaedt, R., Milanesi, L. (eds) Bioinformatics of Genome Regulation and Structure II. Springer, Boston, MA. https://doi.org/10.1007/0-387-29455-4_3
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DOI: https://doi.org/10.1007/0-387-29455-4_3
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-387-29450-6
Online ISBN: 978-0-387-29455-1
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