Central Moments Based Statistical Analysis for the Determination of Functional Sites in Proteins with Thematics

  • L. F. Murga
  • J. Ko
  • Y. Wei
  • M. J. OndrechenEmail author


One of the big challenges in genomics is to obtain information related to protein function. Computational methods that allow fast and accurate determination are needed. We present here the application of a statistical analysis coupled with THEMATICS that allows the fast identification of functional sites in proteins. The method is amenable for automation and thus for the purpose of high throughput analysis. We show the detailed analysis of two proteins and a summary of the application of the method to a set of 15 proteins with diverse functions.

Key words

active site functional genomics titration curves THEMATICS 


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Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  1. 1.Department of Chemistry and Chemical BiologyNortheastern UniversityBostonUSA
  2. 2.Department of ChemistryIndiana University at PennsylvaniaIndianaUSA

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