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Comparative Genomics and Evolution of Bacterial Regulatory Systems

  • M. S. GelfandEmail author
  • A. V. Gerasimova
  • E. A. Kotelnikova
  • O. N. Laikova
  • V. Y. Makeev
  • A. A. Mironov
  • E. M. Panina
  • D. A. Ravcheev
  • D. A. Rodionov
  • A. G. Vitreschak
Chapter
  • 773 Downloads

Abstract

Recent advances in genome sequencing and development of comparative genomics techniques allow one to study evolution of regulation in prokaryotes at several different levels: microevolution of orthologous regulatory sites, changes in regulon content, evolution of interacting regulatory systems, and co-evolution of transcription factors and their binding signals. Regulatory interactions appear to be very dynamic in some cases and surprisingly stable in others. The review presents several examples where comparative analysis uncovered plausible scenarios of evolution of regulatory systems.

Key words

regulation evolution transcription binding site riboswitch 

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Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • M. S. Gelfand
    • 1
    • 2
    • 3
    Email author
  • A. V. Gerasimova
    • 2
  • E. A. Kotelnikova
    • 2
  • O. N. Laikova
    • 2
  • V. Y. Makeev
    • 2
  • A. A. Mironov
    • 2
    • 3
  • E. M. Panina
    • 1
  • D. A. Ravcheev
    • 1
    • 3
  • D. A. Rodionov
    • 1
  • A. G. Vitreschak
    • 1
  1. 1.Institute for Information Transmission ProblemsRussian Academy of SciencesMoscowRussia
  2. 2.State Scientific Center GosNIIGenetikaMoscowRussia
  3. 3.Department of Bioengineering and BioinformaticsMoscow State UniversityMoscowRussia

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