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DNA Nucleosome Organization of the Promoter Gene Regions

  • V. G. LevitskyEmail author
  • A. G. Pichueva
  • A. V. Kochetov
  • L. Milanesi
Chapter
  • 750 Downloads

Abstract

DNA nucleosome organization is an important factor in gene expression patterning. The nature of the context signals determining nucleosome formation sites are not completely understood. Given these considerations, the relation between the nucleosome positioning and the regulation of gene expression appears of great interest. Taxon-specific nucleosome organization of the yeast and mammalian core promoters was identified. The context parameters of the DNA nucleosome organization differ by the distribution pattern in the mammalian and yeast promoters. We suppose that a common nucleosome positioning pattern may exist in promoters regions of mammalian genes. The programs used for nucleosome positioning analysis are available at http://wwwmgs.bionet.nsc.ru/mgs/programs/recon/, http://wwwmgs.bionet.nsc.ru/mgs/programs/phase/.

Key words

gene expression pattern nucleosome positioning periodic dinucleotide density nucleosome formation potential 

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Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • V. G. Levitsky
    • 1
    Email author
  • A. G. Pichueva
    • 1
  • A. V. Kochetov
    • 1
  • L. Milanesi
    • 2
  1. 1.Institute of Cytology and GeneticsSiberian Branch of the Russian Academy of SciencesNovosibirskRussia
  2. 2.Istituto di Tecnologie Biomediche AvanzateSegrate, MilanoItaly

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