DNA Nucleosome Organization of the Promoter Gene Regions
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DNA nucleosome organization is an important factor in gene expression patterning. The nature of the context signals determining nucleosome formation sites are not completely understood. Given these considerations, the relation between the nucleosome positioning and the regulation of gene expression appears of great interest. Taxon-specific nucleosome organization of the yeast and mammalian core promoters was identified. The context parameters of the DNA nucleosome organization differ by the distribution pattern in the mammalian and yeast promoters. We suppose that a common nucleosome positioning pattern may exist in promoters regions of mammalian genes. The programs used for nucleosome positioning analysis are available at http://wwwmgs.bionet.nsc.ru/mgs/programs/recon/, http://wwwmgs.bionet.nsc.ru/mgs/programs/phase/.
Key wordsgene expression pattern nucleosome positioning periodic dinucleotide density nucleosome formation potential
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