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The Role of Unusual DNA Structures in Chromatin Organization for Transcription

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DNA Conformation and Transcription

Part of the book series: Molecular Biology Intelligence Unit ((MBIU))

Abstract

The structural and mechanical properties of DNA influence nudeosome positioning and the manner in which DNA is organized in chromatin. Curved DNA structures, poly(dA·dT) sequences, and Z-DNA-forming sequences frequently occur near transcription start sites. Many reports have indicated that curved DNA structures play an important role in the formation, stability and positioning of nucleosomes, and consequently in DNA packaging in nuclei. Curved DNA structures and poly(dA·dT) sequences can increase the accessibility of target DNA elements of activators in chromatin to facilitate initiation of transcription. Z-DNA seems to be implicated in gene activation coupled with chromatin remodeling, and eukaryotes may use triplex DNA and cruciform structures to manipulate chromatin structure in a site-specific manner.

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  1. Department of Biology Faculty of Science and Engineering, Konan University, Kobe, Japan

    Takashi Ohyama

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Ohyama, T. (2005). The Role of Unusual DNA Structures in Chromatin Organization for Transcription. In: DNA Conformation and Transcription. Molecular Biology Intelligence Unit. Springer, Boston, MA. https://doi.org/10.1007/0-387-29148-2_13

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