Abstract
PITX2 is a paired-related homeobox gene that has been shown to be the mutated gene in Axenfeld-Rieger syndrome (ARS). The focus of this chapter will be to review recent studies that address the role of pitx2 in cardiac morphogenesis. Since ARS patients usually manifest ocular, dental and abdominal wall phenotypes, this review will deal primarily with experiments performed in model systems used to study gene function, such as the mouse.
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Martin, J.F. (2005). The Multiple Roles of Pitx2 in Heart Development. In: The Molecular Mechanisms of Axenfeld-Rieger Syndrome. Medical Intelligence Unit. Springer, Boston, MA. https://doi.org/10.1007/0-387-28672-1_7
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DOI: https://doi.org/10.1007/0-387-28672-1_7
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-387-26222-2
Online ISBN: 978-0-387-28672-3
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