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The Proteasome in Neurodegeneration pp 39–55Cite as

Protein Aggregation and the UPS: A Two-Way Street

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Abstract

The link between protein aggregation and the UPS in the context of neurodegenerative diseases is still a matter of intense debate. Many issues, especially regarding the nature of the interaction between aggregated proteins and the UPS, remain unresolved. Further experiments, especially in an in vivo context, will be needed to address these issues. Such studies may shed light on the importance of the UPS in neurodegeneration.

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Authors and Affiliations

  1. Section of Neurobiology, Institute for Biomedical Research, Academy of Athens, Athens, Greece

    Dr. Kostas Vekrellis & Dr. Leonidas Stefanis

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  1. Dr. Kostas Vekrellis
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  2. Dr. Leonidas Stefanis
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Editors and Affiliations

  1. Institute of Biomedical Research of the Academy of Athens, Athens, Greece

    Leonidas Stefanis

  2. Sanders-Brown Center on Aging Department of Anatomy and Neurobiology, University of Kentucky, KY, USA

    Jeffrey N. Keller

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Vekrellis, K., Stefanis, L. (2006). Protein Aggregation and the UPS: A Two-Way Street. In: Stefanis, L., Keller, J.N. (eds) The Proteasome in Neurodegeneration. Springer, Boston, MA. https://doi.org/10.1007/0-387-28500-8_3

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