Summary
In this chapter, we have outlined the general steps of neurogenesis, and the mechanisms by which these steps occur. For over a hundred years, neurobiologists have described this process by making careful observations of the cellular events that occur as neuroepithelial cells mature into neurons. These observations provided much of the groundwork for later studies and correctly predicted many of the mechanisms that were subsequently discovered. Recently, advances in molecular techniques have allowed us to understand how genetic and biochemical events control the progression from stem cells into differentiated neurons. At this point, we can observe a single neuron and know many of the genes that regulate every step of its differentiation. One important next step is to recapitulate this process in vitro to see if we can direct the differentiation of stem cells or progenitors in a carefully controlled environment. If successful, this work has the potential to provide therapy for human nervous system injury and disease.
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Vetter, M.L., Dorsky, R.I. (2005). Neurogenesis. In: Rao, M.S., Jacobson†, M. (eds) Developmental Neurobiology. Springer, Boston, MA. https://doi.org/10.1007/0-387-28117-7_5
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