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Sperm Maturation in Epididymis

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Proteomics of Spermatogenesis

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34.7. References

  • Aitken RJ, Vernet P. Maturation of redox regulatory mechanisms in the epididymis. J Reprod Fertil Suppl 1998; 53: 109–18.

    CAS  PubMed  Google Scholar 

  • Araki Y, Vierula ME, Rankin TL, Tulsiani DR, Orgebin-Crist MC. Isolation and characterization of a 25-kilodalton protein from mouse testis: sequence homology with a phospholipids-binding protein. Biol Reprod 1992; 47: 832–43.

    Article  CAS  PubMed  Google Scholar 

  • Arienti G, Carlini E, Polci A, Cosmi EV, Palmerini CA. Fatty acid pattern of human prostasome lipid. Arch Biochem Biophys 1998; 358: 391–5.

    Article  CAS  PubMed  Google Scholar 

  • Barua M, Nath D, Majumder GC. Alteration of goat sperm ecto-phosphoprotein phosphatase activity and its distribution on the sperm surface during epididymal maturation. Reprod Fertil Dev 2001; 13: 443–50.

    Article  CAS  PubMed  Google Scholar 

  • Blobel CP. Functional processing of fertilin: evidence for a critical role of proteolysis in sperm maturation and activation. Rev Reprod 2000; 5; 75–83.

    Article  CAS  PubMed  Google Scholar 

  • Boue F, Duquenne C, Lassalle B, Lefevre A, Finaz C. FLB1, a human protein of epididymal origin that is involved in the sperm-oocyte recognition process. Biol Reprod 1995; 52: 267–78.

    Article  CAS  PubMed  Google Scholar 

  • Carballada R. Esponda P. Regulation of foreign DNA uptake by mouse spermatozoa. Exp Cell Res 2001; 262:104–13.

    Article  CAS  PubMed  Google Scholar 

  • Cohen DJ, Rochwerger L, Ellerman DA, Morgenfeid MM. Busso D, Cuasnicu PS. Relationship between the association of rat epididymal protein “DE” with spermatozoa and the behaviour and function of the protein. Mol Reprod Dev 2000; 56: 180–8.

    Article  CAS  PubMed  Google Scholar 

  • Cooper TG. Interactions between epididymal secretions and spermatozoa. J Reprod Fertil (Suppl) 1998; 53:119–36.

    CAS  Google Scholar 

  • Cornwall GA, Cameron A, Lindberg I, Hardy DM, Cormier N, Hsia N. The cystatin-related epididymal spermatogenic protein inhibits the serine protease prohormone convertase 2. Endocrinology 2003;144: 901–8.

    Article  CAS  PubMed  Google Scholar 

  • Cornwall GA, Harm SR. Transient appearance of CRES protein during spermatogenesis and caput epididymal sperm maturation. Mol Reprod Dev 1995; 41: 37–46.

    Article  CAS  PubMed  Google Scholar 

  • Dacheux JL, Druart X, Fouchecourt S, Syntin P, Gatti JL, Okamura N, Dachexu F. Role of epididymal secretory proteins in sperm maturation with particular reference to the boar. J Reprod Fert (Suppl) 1998; 53: 99–107.

    CAS  Google Scholar 

  • Diekman AB, Norton EJ, Klotz KL, Westbrook VA, Nabby-Hansen S, Herr JC. Evidence for a unique N-linked glycan associated with human infertility on sperm CD52: a candidate cotraceptive vaccinogen. Am J Reprod Immunol 1999b; 43; 134–43.

    Article  Google Scholar 

  • Diekman AB, Norton EJ, Klotz KL, Westbrook VA, Shibahara H, Naaby-Hansen N, Flickinger CJ. and Herr J.C. N-linked glycan of a sperm CD52 glycoform associated with human infertility. FASEB J 1999a; 13: 1303–13.

    CAS  PubMed  Google Scholar 

  • Diekman AB, Norton EJ, Westbrook VA, Klotz KL, Nabby-Hansen S, Herr JC. Antisperm antibodies from infertile patients and their cognate sperm antigens: a review. Identity between SAGA-1 the H6-3C4 antigen and CD52. Am J Reprod Immunol 2000; 43: 134–43.

    Article  CAS  PubMed  Google Scholar 

  • Eccleston ED, White TW, Howard JB, Hamilton DW. Characterization of a cell surface glycoprotein associated with maturation of rat spermatozoa. Mol Reprod Dev 1994; 37: 110–19.

    Article  CAS  PubMed  Google Scholar 

  • Ellerbrock K, Pera I, Hartung S, Ivell R. Gene expression in the dog epididymis: a model for human epididymal function. Int J Androl 1994; 17: 314–23.

    Article  CAS  PubMed  Google Scholar 

  • Ellerman DA, Brantua VS, Penz-Martinez S, Cohen DJ, Conesa D, Cuasnicu PS. Potential contraceptive use of epididymal proteins. Immunization of male rats with epididymal protein DE inhibits sperm fusion ability. Biol Reprod 1998; 59 1029–36.

    Article  CAS  PubMed  Google Scholar 

  • Ellerman DA, Da Ros VG, Cohen DJ, Busso D, Morgenfeid MM. Expression and structure-function analysis of DE, a sperm cysteine-rich seretory protein that mediates gamete fusion. Biol Reprod 2002; 67:1225–31.

    Article  CAS  PubMed  Google Scholar 

  • Fan HY, Miao SY, Wang LF, Koide SS. Expression and characterization of an epididymis specific gene. Arch Androl 1999; 42: 63–9.

    Article  CAS  PubMed  Google Scholar 

  • Feuchter FA, Tabet AJ, Green MF. Maturation antigen of the mouse sperm flagellum. I. Analysis of its secretion, association with sperm, and function. Am J Anat 1988; 181: 67–76.

    Article  CAS  PubMed  Google Scholar 

  • Focarelli R, Francavilla S, Francavilla F, Giovampaola CD, Santucci A, Rosati F. A sialoglycoprotein, gp20, of the human capacitated sperm surface is a homologue of the leukocyte CD52 antigen: analysis of the effect of anit-CD52 monoclonal antibody on capacitated spermatozoa. Mol Hum Reprod 1999a; 5: 46–51.

    Article  CAS  PubMed  Google Scholar 

  • Focarelli R, Giuffrida A, Capparelli S, Schibona M et al. Specific localization in the equatorial region of gp20, a 20 kDa sialyglycoprotein of the capacitated human spermatozoon acquired during epididymal transit which is necessary to penetrate zona-free hamster eggs. Mol Human Reprod 1998; 4: 119–25.

    Article  CAS  Google Scholar 

  • Frayne J, Hall L. The gene for the human tMDC 1 sperm surface protein is non-functional: implications for its proposed role in mammalian sperm-egg recognition. Biochem J 1998; 334 (PEI): 171–6.

    PubMed Central  CAS  PubMed  Google Scholar 

  • Frohlich O, Po C, Young LG. Characterization of human gene encoding the epididymis specific EP2 protein variants and its relationship to defensin genes. Biol Reprod 2001 64: 1072–9.

    Article  CAS  PubMed  Google Scholar 

  • Frohlich O, Young LG. Molecular cloning and characterization of EPI-1, the major protein in chimpanzee (pan troglodytes) cauda epididymal fluid. Biol Reprod 1996; 54: 857–64.

    Article  CAS  PubMed  Google Scholar 

  • Gatti JL, Druart X, Syntin P, Guerin Y, Dacheux JL, Dacheux F. Biochemical characterization of two ram caude epididymal maturation — dependent sperm glycoproteins. Biol Reprod 2000; 62: 950–8.

    Article  CAS  PubMed  Google Scholar 

  • Giese A, Jude R, Kuiper H, Piumi F, Schambony A, Guerin G, Distl O, Topfer-Petersen E, Leeb T. Molecular characterization of the equine AEG1 locus. Gene. 2002a; 292: 65–72.

    Article  CAS  PubMed  Google Scholar 

  • Giese A, Jude R, Kuiper H, Raudsepp T, Piumi F, Schambony A, Guerin G, Chowdhary BP, Distl O, Topfer-Petersen E, Leeb T. Molecular characterization of the equine testis-specific protein 1 (TPX1) and acidic epididymal glycoprotein 2 (AEG2) genes encoding members of the cysteine-rich secretory protein (CRISP) family. Gene 2002b; 299: 101–09.

    Article  CAS  PubMed  Google Scholar 

  • Giovampaola CD, Flori F, Sabatini L, Incerti L, LA Sala GB, Rosati F, Focarelli R. The surface of human sperm bears three differently charged CD52 glycoforms two of which remain stably bound to sperm after capacitation. Mol Reprod Dev 2000 (Submitted).

    Google Scholar 

  • Hale G, Bartholomeco M, Taylor V, Stables J, Topley P, Tile J, Recognition of CD52 allelic gene products by CAMPATH-1 H antibodies. Immunology 1996; 88: 183–90.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Hall JC, Killian GJ. Changes in rat sperm membrane glycosidase activities and carbohydrate and protein contents associated with epididymal transit. Biol Reprod 1987; 36: 709–18.

    Article  CAS  PubMed  Google Scholar 

  • Hall JC, Reddy NG. Protein D is differentially expressed and regulated in the rat epididymis. Biochem Biophys Res Commun 1992; 31: 1109–16.

    Article  Google Scholar 

  • Hamil KG, Sivashanmugam P, T. Richardson RT, Grossman G, Ruben SM et al. HE2β and HE2γ, new members of an epididymis-specific family of androgen-regulated proteins in the human. Endocrinology 2000; 141: 1245–53

    CAS  PubMed  Google Scholar 

  • Harayama H, Kato S, Hammerstedt RH. Electrophoretic characterization of boar epididymal antiagglutinin. Biol Reprod 1996; 55: 325–32.

    Article  CAS  PubMed  Google Scholar 

  • Harayama H, Miyake M, Kato S, Immunolocalization of anti-agglutinin for spermatozoa in boars. Mol Reprod Dev 1999; 52: 269–76.

    Article  CAS  PubMed  Google Scholar 

  • Hellsten E, Evans JP, Bernard DJ, Janne PA, Nussbaum RL. Disrupted sperm function and fertilin beta processing in mice deficient in the inositol polyphosphate 5-phosphatase Inpp5b. Dev Biol 2001; 240:641–53.

    Article  CAS  PubMed  Google Scholar 

  • Hermo L, Andonian S. Regulation of sulfated glycoprotein-1 and cathepsin D expression in adult rat epididymis. J Androl 2003; 24: 408–22.

    PubMed  Google Scholar 

  • Hinton BT, Lan ZJ, Rudolph DB, Labus JC, Lye RJ. Testicular regulation of epididymal gene expression. J Reprod Fertil 1998; 53: 47–57.

    CAS  Google Scholar 

  • Hinton BT, Palladino MA. Epididymal epithelium: its contribution to the formation of adluminal fluid microenvironment. Microsc Res Tech 1995; 30: 67–81.

    Article  CAS  PubMed  Google Scholar 

  • Howes EA, Hurst SM, Jones R. Actin and actin-binding proteins in bovine spermatozoa: potential role in membrane remodeling and intracellular signaling during epididymal maturation and the acrosome reaction. J Androl 2001; 22: 62–72.

    CAS  PubMed  Google Scholar 

  • Hsia N, Cornwall GA. Cres2 and Cres3: new members of the cystatin-related epididymal spermatogenic subgroup of family 2 cystatins. Endocrinology 2003; 144: 909–15.

    Article  CAS  PubMed  Google Scholar 

  • Hunnicutt GR, Koppel DE, Myles DG. Analysis of the process of localization of fertilin to the sperm posterior head plasma membrane domain during sperm maturation in the epididymis. Dev Biol 1997;191: 146–59.

    Article  CAS  PubMed  Google Scholar 

  • Ibrahim NM, Troedsson MH, Foster DN, Loseth KJ, Farris JA, Blaschuk O, Crabo BG. Reproductive tract secretions and bull spermatozoa contain different clusterin isoforms that cluster cells and inhibit complement-induced cytolysis. J Androl 1999; 20: 230–40.

    CAS  PubMed  Google Scholar 

  • Isojima S, Kameda K, Tsuji Y, Shigeta M, Ikeda Y, Koyama K. Establishment and chacterization of a human hybridoma secreting monoclonal antibody with high titers of sperm immobilizing and agglutination activities against human seminal plasma. J. Reprod Immunol 1987; 10: 67–78.

    Article  CAS  PubMed  Google Scholar 

  • Ivell R, Pera I, Ellerbrock K, Beiglbock A, Gebhardt K, Osterhoff C, Kirchhoff C. The dog as a model system to study epididymal gene expression. J Reprod Fertil (Suppl) 1998; 53: 33–45.

    CAS  Google Scholar 

  • Jones R, Ma A, Hou ST, Shalgi R, Hall L. Testicular biosynthesis and epididymal endoproteolytic processing of rat sperm surface antigen 2B1. J Cell Sci 1996; 109: 2561–70.

    CAS  PubMed  Google Scholar 

  • Jones R. Maturation in the epididymis. J Reprod Fertil (Suppl) 1998; 53: 73–84.

    CAS  Google Scholar 

  • Jury JA, Frayne J, Hall L. Sequence analysis of a variety of primate fertilin a genes: evidence for non-functional genes in the gorilla and man. Mol Reprod Dev 1998; 51: 92–7.

    Article  CAS  PubMed  Google Scholar 

  • Kirchhoff C, Krull N, Pera I, Ivell R. A major mRNA of the human epididymal principal cells, HE5, encodes the leucocyte differentiation CDw52 antigen peptide backbone. Mol Reprod Dev 1993; 34: 8–15.

    Article  CAS  PubMed  Google Scholar 

  • Kirchhoff C, Osterhoff C, Pera I, Schroter S. Function of human epididymal proteins in sperm maturation. Andrologia 1998a; 30: 225–32.

    Article  CAS  PubMed  Google Scholar 

  • Kirchhoff C, Osterhoff C, Young L. Molecular cloning and characterization of HE1, a major secretory protein of human epididymis Biol Reprod 1998b; 54: 847–56.

    Article  Google Scholar 

  • Kirchhoff C. Gene expression in the epididymis. Int Rev Cytol 1999; 188: 133–202.

    Article  CAS  PubMed  Google Scholar 

  • Kratzschmar J, Haendler B, Eberspaecher U, Roosterman D, Donner P, Schleuning WD. The human cysteine-rich secretory protein (CRISP) family. Primary structure and tissue distribution of CRISP-1, CRISP-2 and CRISP-3. Eur J Biochem 1996; 15: 827–36.

    Article  Google Scholar 

  • Kravets FG, Lee J, Singh B, Trocchia A, Pentyala SN, Khan SA. Prostasomes: current concepts. Prostate 2000; 43: 169–74.

    Article  CAS  PubMed  Google Scholar 

  • Lareyre JJ, Winfrey VP, Kasper S, et al. Gene duplication gives rise to a new 17-kilodalton lipocalin that shows epididymal region-specific expression and testicular factor(s) regulation. Endocrinology 2000;20: 261–74.

    Google Scholar 

  • Legare C, Berube B, Boue F, Lefievre L, Morales CR, B-Alfy M, Sullivan R. Hamster sperm antigen P26h is a phosphatidylinositol-anchored protein. Mol Reprod Dev 1999a; 52: 225–33.

    Article  CAS  PubMed  Google Scholar 

  • Legare C, Gaudreault C, St-Jacques S, Sullivan R. P34H sperm protein is preferentially expressed by the human corpus epididymidis. Endocrinology 1999b; 140: 3318–27.

    CAS  PubMed  Google Scholar 

  • Legare C, Thabet M, Picard S, Sullivan R. Effect of vasectomy on P34H messenger ribonucleic acid expression along the human excurrent duct: a reflection on the function of the human epididymis. Biol Reprod 2001; 64: 720–7.

    Article  CAS  PubMed  Google Scholar 

  • Li P, Chan HC, He B, et al. An antimicrobial peptide gene found in the male reproductive system of rats. Sci 2001; 291: 1783–85.

    Article  CAS  Google Scholar 

  • Li Y, Friel PJ, Robinson MO, McLean DJ, Griswold MD. Identification and characterization of testis-and epididymis-specific genes: cystatin SC and cystatin TE-1. Biol Reprod 2002; 67: 1872–80.

    Article  CAS  PubMed  Google Scholar 

  • Linder B, Bammer S, Heinlein UA. Delayed translation and posttranslational processing of cyritestin, an integral transmembrane protein of the mouse acrosome. Exp Cell Res 1995; 221: 66–72.

    Article  CAS  PubMed  Google Scholar 

  • Liu HW, Sun GH, Shy SR, Shyu HY. Postnatal development and testosterone-dependence of GP-83 and GP-49, two sperm maturation related glycoprotions in BALB/c mouse epididymis. Cell Tissue Res 1992;269: 189–94.

    Article  CAS  PubMed  Google Scholar 

  • Liu Q, Hamil KG., Sivashanmugam P, Grossman G, Soundararajan R, Jagannadha Rao A et al,. Primate epididymis specific proteins characterization of ESC42, a novel protein containing a trefoil like motif in monkey and human. Endocrinology 2001; 142: 4529–39.

    Article  CAS  PubMed  Google Scholar 

  • Lum L, Blobel CP. Evidence for distinct serine protease activities with a potential role in processing the sperm protein fertilin. Dev Biol 1997; 191: 131–45.

    Article  CAS  PubMed  Google Scholar 

  • Marshburn PB, Clark MR, Shabanowitz RB. Immunohistochemical localization of prostaglandin H synthase in the epididymis and vas deferens of the mouse. Biol Reprod 1989; 41: 491–7.

    Article  CAS  PubMed  Google Scholar 

  • McCauley TC, Kurth BE, Norton EJ, et al., Analysis of a human sperm CD52 glycoform in primates: Identification of an animal model for immunocontraceptive vaccine development. Biol Reprod 2002;66: 1681–88.

    Article  PubMed  Google Scholar 

  • McLaughlin EA, Frayne J, Barker HL, Jury JA, Jones R, Ford WC, Hall L. Cloning and sequence analysis of rat fertilin α and β developmental expression, processing and immunolocalization. Mol Hum Reprod 1997; 3: 801–9.

    Article  CAS  PubMed  Google Scholar 

  • Miranda PV, Tezon JG. Characterization of fibronectin as a marker for human epididymal sperm maturation. Mol Reprod Dev 1992; 33: 443–50.

    Article  CAS  PubMed  Google Scholar 

  • Moore A, Ensrud KM, White TW, Frethem CD, Hamilton DW. Rat epididymis specific sperm maturation antigens. I. Evidence that the 26 kD 4E9 antigen found on rat caudal epididymal sperm tail is derived from a protein secreted by the epididymis. Mol Reprod Dev 1994; 37: 181–94.

    Article  CAS  PubMed  Google Scholar 

  • NagDas SK, Winfrey VP, Olson GE. Identification of a hamster epididymal region-specific secretory glycoprotein that binds nonviable spermatozoa. Biol Reprod 2000; 63: 1428–36.

    Article  CAS  PubMed  Google Scholar 

  • Nath D, Majumder GC. Maturation dependent modification of the protein phosphorylation profile of isolated goat sperm plasma membrane. J Reprod Fertil 1999; 115: 29–37.

    Article  CAS  PubMed  Google Scholar 

  • Nixon B, Hardy CM, Jones RC, Andrews JB, Holland MK. Rabbit epididymal secretory proteins. III. Molecular cloning and characterization of the complementary DNA for REP38. Biol Reprod 2002b; 67: 147–52.

    Article  CAS  PubMed  Google Scholar 

  • Nixon B, Jones RC, Clarke HG, Holland MK. Rabbit epididymal seretory proteins. II. Immunolocalization and sperm association of REP38. Biol Reprod 2002; 67: 140–46.

    Article  CAS  PubMed  Google Scholar 

  • Obermann H, Samalecos A, Osterhoff C, Schroder B, Heller R, Kirchhoff C. HE6, a two-subunit heptahelical receptor associated with apical membranes of efferent and epididymal duct epithelia. Mol Reprod Dev 2003; 64:13–26.

    Article  CAS  PubMed  Google Scholar 

  • Okamura N, Dacheux F, Venien A, Onoe S, Huet JC, Dacheux JL. Localization of a maturation-dependent epididymal sperm surface antigen recognized by a monoclonal antibody raised against a 135-kilodalton protein in porcine epididymal fluid. Biol Reprod 1992; 47: 1040–52.

    Article  CAS  PubMed  Google Scholar 

  • Okamura N, Kiuchi S, Tamba M, Kashima T, Hiramoto S et al. A porcine homolog of the major secretory protein of human epididymis HE1, specifically binds cholesterol. Biochim Biophys Acta 1999; 1438:377–87.

    Article  CAS  PubMed  Google Scholar 

  • Olson JH, Xiang X, Ziegert T, Kittelson A, Rawls A, Bieber AL, Chandler DE. Allurin, a 210kDa sperm chemoattractant from Xenopus egg jelly, is related to mammalian sperm-binding proteins. Proc Natl Acad Sci USA 2001; 98: 11205–10.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Osterhoff C, Kirchhoff C, Krull N, Ivell R. Molecular cloning and characterization of a novel human sperm antigen (HE2), specifically expressed in the proximal epididymis. Biol Reprod 1994; 50: 576–25.

    Article  Google Scholar 

  • Perry ACF, Jones R, Hall L. The monkey ESP14.6 mRNA, a novel transcript at high levels in the epididymis. Gene 1995; 153: 291–92.

    Article  CAS  PubMed  Google Scholar 

  • Perry ACF, Jones R, Moisyadi S, Coadwell J, Hall L. The novel epididymal secretory protein ESP13.2 in Macaca fasicularis. Biol Reprod 1999; 61: 965–72.

    Article  CAS  PubMed  Google Scholar 

  • Petruszak JA, Nehme CL, Bartles JR. Endoproteolytic cleavage in the extracellular domain of the inegral plasma membrane protein CE9 precedes its redistribution from the posterior to the anterior tail of the rat spermatozoon during epididymal maturation. J Cell Biol 1991; 114: 917–27.

    Article  CAS  PubMed  Google Scholar 

  • Ram PA, Cardullo RA, Millette CF. Expression and topographical localization of cell surface fucosyltransferase activity during epididymal sperm maturation in the mouse. Gamete Res 1989; 22: 321–22.

    Article  CAS  PubMed  Google Scholar 

  • Rane APS, Majumder GC, Misra S, Ghosh A. Lipid changes of goat sperm plasma membrane during epididymal maturation. Biochim Biophys Acta 1991; 1061: 185–96.

    Article  Google Scholar 

  • Rankin TL, Tsuruta KJ, Holiand MK, Griswald MD, Orgebin Crist MC. Isolation, immunolocalization and sperm-association of three proteins of 18, 25, and 29 kilodaltons secreted by the mouse epididymis. Biol Reprod 1992; 46: 747–66.

    Article  CAS  PubMed  Google Scholar 

  • Rao J, Herr JC, Reddi PP, Wolkowicz MJ, Bush LA, Sherman NE, Black M, Flickinger CJ. Cloning and characterization of a novel sperm-associated isoantigen (E-3) with defensin-and lectin-like motifs expressed in rat epididymis. Biol Reprod 2003; 68: 290–301.

    Article  CAS  PubMed  Google Scholar 

  • Retamal C, Urzua J, Alves EW, Lopez ML. Cytochemical and electrophoretic study of the stallion epididymal glycoproteins. J Submicrosc Cytol Pathol 2000; 32: 117–30.

    CAS  PubMed  Google Scholar 

  • Roberts KP, Ensrud KM, Hamilton DW. A comparative analysis of expression and processing of the rat epididymal fluid and sperm-bound forms of proteins D and E. Biol Reprod 2002; 67: 525–33.

    Article  CAS  PubMed  Google Scholar 

  • Rosenberg ME, Silkensen J. Clusterin: physiologic and pathophysiologic considerations. Int J Biochem Cell Biol 1995; 27: 633–45.

    Article  CAS  PubMed  Google Scholar 

  • Rutllant J, Meyers SA. Posttranslational processing of PH-20 during epididymal sperm maturation in the horse. Biol Reprod 2001; 65: 1324–31.

    Article  CAS  PubMed  Google Scholar 

  • Saalmann A, Munz S, Ellerbrock K, Ivell R, Kirchhoff C. Novel sperm-binding proteins of epididymal origin contain four fibronectin type II-modules. Mol Reprod and Dev 2001; 58: 88–100.

    Article  CAS  Google Scholar 

  • Sarkar M, Chatterjee T. Distribution of 105-kDa sperm unique antigen on goat epididymal mature spermatozoa. Biochem Biophys Res Commun 1997; 231: 662–6.

    Article  CAS  PubMed  Google Scholar 

  • Scarlett CJ, Lin M, Aitken RJ. Actin polymerization during morphogenesis of the acrosome as spermatozoa undergo epididymal maturation in the tammar wallaby (Macropus eugenii). J Anat 2001; 198; 93–101.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Schambony A, Hess O, Gentzel M, Topfer-Petersen E. Expression of CRISP proteins in the male equine gential tract. J Reprod Fertil (Suppl) 1998; 53: 67–72.

    CAS  Google Scholar 

  • Schroter S, Derr P, Conradt HS, Nimtz M. Hale G, Kirchhoff C. Male specific modification of human CD52. J Biol Chem 1999; 274: 29862–73.

    Article  CAS  PubMed  Google Scholar 

  • Sensibar JA, Qian Y, Griswold MD, Sylvester SR, Bardin CW, Cheng CY, Lee C. Localization and molecular heterogeneity of sulfated glycoprotein-2 (clusterin) among ventral prostate, seminal vesicle, testis, and epididymis of rats. Biol Reprod 1993; 49: 233–42.

    Article  CAS  PubMed  Google Scholar 

  • Sirivaidyapong S, Bevers MM, Gadella BM, Colenbrander B. Induction of the acrosome reaction in dog sperm cells is dependent on epididymal maturation. Mol Reprod Dev 2001; 58: 451–9.

    Article  CAS  PubMed  Google Scholar 

  • Sivashanmugam P, Richardson RT, Hall S, Hamil KG, French FS, O, Rand MG. Cloning and characterization of an androgen-dependent acidic epididymal glycoprotein/CRISP-1 like protein from the monkey. J Androl 1999; 20: 384–93.

    CAS  PubMed  Google Scholar 

  • Smithwick EB, Young LG. Immunohistochemical localization of epididymal secretory glycoprotein EP1 in the adult male chimpanzee. Tissue Cell 1999; 31: 54–65.

    Article  CAS  PubMed  Google Scholar 

  • Srivastav A. Maturation dependent glycoproteins containing both N-and O-linked oligosacharides in epididymal sperm plasma membrane of rhesus monkeys (Macaca Mulatta). J. Reprod Fert 2000; 119:241–52.

    Article  CAS  Google Scholar 

  • Sun GH, Lin YC, Guo YW, Chang SY, Lin HW. Purification of GP-83, a glycoprotein secreted by the human epididymis and conjugated to mature spermatozoa. Mol Hum Reprod 2000; 6: 429–34.

    Article  CAS  PubMed  Google Scholar 

  • Sundaram M, Sivaprasadarao A, Aalten DM, Findlay JB. Expression, characterization and engineered specificity of rat epididymal retinoic acid-binding protein. Biochem J 1998; 334: 155–60.

    PubMed Central  CAS  PubMed  Google Scholar 

  • Sutovsky P, Moreno R, Ramalho-Santos J, Dominko T, Thomoson WE, Schatten G. Putative ubiquitin dependent mechanism for the recognition and elimination of defective spermatozoa in mammalian epididymis. J Cell Sci 2001; 114 (Pt a): 1665–75.

    CAS  PubMed  Google Scholar 

  • Syntin P, Cornwall GA. Immunolocalization of CRES (Cystatin-Related Epididymal Speratogenic) protein in the acrosomes of mouse spermatozoa. Biol Reprod 1999; 60: 1542–52.

    Article  CAS  PubMed  Google Scholar 

  • Syntin P, Dacheux F, Druart X, Gatti JL. Characterization and identification of proteins secreted in the various regions of the adult boar epididymis. Biol Reprod 1996; 55: 956–974.

    Article  CAS  PubMed  Google Scholar 

  • Toshimori K, Araki S, Oura C. Masking of sperm maturation antigen by sialic acid in the epididymis of the mouse. An Immunohistochemical study. Histochem 1988; 90: 195–200.

    Article  CAS  Google Scholar 

  • Toshimori K, Tanii I, Araki S. Intra-acrosomal 155,000 dalton protein increases the antigenicity during mouse sperm maturation in the epididymis: a study using a monoclonal antibody MC101. Mot Reprod Dev 1995; 42: 72–9.

    Article  CAS  Google Scholar 

  • Tsuji Y, Clausen H, Nudelman E, Kaizu T, Hakomori SI, Isojima S. Human sperm carbohydrate antigens defined by an antrisperm human monoclonal antibody derived from an infertile woman bearing antisperm antibodies in her serum. J Exp Med 1988; 168: 343–56.

    Article  CAS  PubMed  Google Scholar 

  • Tubbs CE, Hall JC, Scott RO, Clark VP, Hermon TL, Bazemore-Walker C. Binding of protein D/E to the surface of rat epididymal sperm before ejaculation and after deposition in the female reproductive tract. J Androl 2002; 23: 512–21.

    CAS  PubMed  Google Scholar 

  • Tulsiani Dr, NagDas SK, Skudlarek MD, Orgebin-Crist MC. Rat sperm plasma membrane mannosidase: localization and evidence for Proteolytic processing during epididymal maturation. Dev Biol 1995; 167:584–95.

    Article  CAS  PubMed  Google Scholar 

  • Tulsiani DRP, Orgebin-Crist MC, Skudlarek MD. Role of luminal fluid glycosyltransferases and glycosidases in the modification of rat sperm plasma membrane glycoproteins during epididymal maturation. J Reprod Fert (Suppl). 1998; 53,85–97.

    CAS  Google Scholar 

  • Uma Devi, Basheer Ahmad M, Shivaji S. A maturation related differential phosphorylation of the plasma membrane proteins of the epididymal spermatozoa of hamster by endogenous protein kinases. Mol Reprod Dev 1997; 47: 341–50.

    Article  Google Scholar 

  • Vierula ME, Araki Y, Rankin TL, Tulsiani DR, Orgebin-Crist MC. Immunolocalization of a 25-kilodalton protein in mouse testis and epididymis. Biol Reprod 1992; 47: 844–56.

    Article  CAS  PubMed  Google Scholar 

  • Voglmayr JK, Sawyer RF Jr, Dacheux JL. Glycoproteins: a variable factor in surface transformation of ram spermatozoa during epididymal transit. Biol Reprod 1985; 33: 165–76.

    Article  CAS  PubMed  Google Scholar 

  • Wassler M, Syntin P, Sutton-Walsh HG, Hsia N, Hardy DM, Cornwall GA. Identification and characterization of cystatin-related epididymal spermatogenic protein in human spermatozoa: localization in the equatorial segment. Biol Reprod 2002; 67: 795–803.

    Article  CAS  PubMed  Google Scholar 

  • Waters SI, White JM. Biochemical and molecular characterization of bovine fertilin a and b (ADAM1 and ADAM2): A candidate sperm-egg binding/fusion complex. Biol Reprod 1997; 56: 1245–54.

    Article  CAS  PubMed  Google Scholar 

  • Weaver FE, Dino JE, Germain BJ, Wolf DE, Fairbanks G. Biochemical characterization and epididymal localization of the maturation dependent ram sperm surface antigen ESA152. Mol Reprod Dev 1993;35: 293–301.

    Article  CAS  PubMed  Google Scholar 

  • Wong P, Taillefer D, Lakins J, Pineault J, Chander G et al etc. Molecular characterization of human TRPM-2/clusterin, a gene associated with sperm maturation, apoptosis and neurodegeneration. Eur J Biochem 1994; 221: 917–25.

    Article  CAS  PubMed  Google Scholar 

  • Xu WD, Wang LF, Miao SY, Zhao M, Fan HY, Zong SD, Wu YW, Shi XQ, Koide SS. Identification of a rabbit epididymal protein gene. Arch Androl 1996; 37: 135–41.

    Article  CAS  PubMed  Google Scholar 

  • Yeung CH, Cooper TG, WeinBauer GF. Maturation of monkey spermatozoa in the epididymis with respect to their ability to undergo the acrosome reaction. J Androl 1996; 17: 427–32.

    CAS  PubMed  Google Scholar 

  • Yeung CH, Perez-Sanchez F, Schroter S, Kirchhoff C, Cooper TG. Changes of the major sperm maturation associated epididymal protein HE5 (CD52) on human ejaculated spermatozoa during incubation. Mol Hum Reprod 2001; 7: 617–24.

    Article  CAS  PubMed  Google Scholar 

  • Yeung CH, Schroter S, Kirchhoff C, Cooper TG. Maturational changes of the CD52 like epididymal glycoprotein on cynomologus monkey sperm and their apparent reversal in capacitation conditions. Mol Reprod Dev 2000; 57: 280–9.

    Article  CAS  PubMed  Google Scholar 

  • Yoshinaga K, Tanii I, Oh-oka T, Toshimori K. Changes in distribution and molecular weight of the acrosomal protein acrin2 (MC41) during guinea pig spermiogenesis and epididymal maturation. Cell Tissue Res 2001; 303: 253–61.

    Article  CAS  PubMed  Google Scholar 

  • Yoshinaga K, Tanii I, Oh-oka T, Toshimori K. Transport and rearrangement of the intra-acrosomal protein acrinl (MN7) during spermiogenesis in the guinea pig testis. Anat Rec 2000; 259: 131–40.

    Article  CAS  PubMed  Google Scholar 

  • Yuan R, Primakoff P, Myles PG. A role for the disintegrin domain of cyritestin, a sperm surface protein belonging to the ADAM family, in mouse sperm-egg plasma membrane adhesion and fusion. J Cell Biol 1997; 137: 105–12.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Zeheb R, Orr GA. Characterization of a maturation-associated glycoprotein on the plasma membrane of rat caudal epididymal sperm. J Biol Chem 1984; 259: 839–48.

    CAS  PubMed  Google Scholar 

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  1. Department of Biophysics, Panjab University, Chandigarh, 160014, India

    Dr. G. S. Gupta Ph.D. (Former Professor and Chairman)

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  1. Dr. G. S. Gupta Ph.D.
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Gupta, G.S. (2005). Sperm Maturation in Epididymis. In: Proteomics of Spermatogenesis. Springer, Boston, MA. https://doi.org/10.1007/0-387-27655-6_34

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