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The Structure and Mechanism of myo-Inositol-1-Phosphate Synthase

  • Chapter
Biology of Inositols and Phosphoinositides

Part of the book series: Subcellular Biochemistry ((SCBI,volume 39))

Abstract

The first and rate-limiting step in the biosynthesis of myo-inositol is the conversion of D-glucose 6-phosphate to 1L-myo-inositol 1-phosphate catalyzed by 1L-myo-inositol 1-phosphate synthase (MIP synthase). MIP synthase has been identified in a wide variety of organisms from bacteria to humans and is relatively well-conserved throughout evolution. It is probably homotetrameric in most if not all cases and always requires NAD+ as a cofactor, with NADH being reconverted to NAD+ in the catalytic cycle. This review focuses on the structure and mechanism of MIP synthase, with a particular emphasis on the mechanistic insights that have come from several recent structures of the enzyme. These include the structure of the enzyme from Saccharomyces cerevisiae, Archeoglobus fulgidus and Mycobacterium tuberculosis.

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Authors and Affiliations

  1. Chemistry Department, Michigan State University, East Lansing, MI, 48824, USA

    James H. Geiger & Xiangshu Jin

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  1. James H. Geiger
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  2. Xiangshu Jin
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Editors and Affiliations

  1. Bose Institute, Kolkata, India

    A. Lahiri Majumder

  2. University College of Science, Kolkata, India

    B. B. Biswas

  3. University of Calcutta, Kolkata, India

    B. B. Biswas

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Geiger, J.H., Jin, X. (2006). The Structure and Mechanism of myo-Inositol-1-Phosphate Synthase. In: Majumder, A.L., Biswas, B.B. (eds) Biology of Inositols and Phosphoinositides. Subcellular Biochemistry, vol 39. Springer, Boston, MA . https://doi.org/10.1007/0-387-27600-9_7

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