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Mammalian Inositol 3-phosphate Synthase: Its Role in the Biosynthesis of Brain Inositol and its Clinical Use as a Psychoactive Agent

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Biology of Inositols and Phosphoinositides

Part of the book series: Subcellular Biochemistry ((SCBI,volume 39))

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References

  • Adhikari, J., and Majumder, A.L., 1988, L-myo-inositol-1-phosphate synthase from mammalian brain: Partial purification and characterisation of the fetal and adult enzyme. Indian J. Biochem. Biophys. 25: 408–412.

    PubMed  CAS  Google Scholar 

  • Agam, G., Shamir, A., Shaltiel, G., and Greenberg, M.L., 2002, Myo-inositol-1-phosphate (MIP) synthase: A possible new target for antibipolar drugs. Bipolar Disord. Suppl. 4: 15–20.

    Article  Google Scholar 

  • Agranoff, B.W., and Fisher, S.K., 2001, Inositol, lithium and the brain. Psychopharmacol. Bull. 35: 5–8.

    PubMed  CAS  Google Scholar 

  • Allison, J.H., and Stewart, M.A., 1971, Reduced brain inositol in lithium treated rats. Nature New Biol. 233: 262–268.

    Article  Google Scholar 

  • Atack, J.R., 1996, Inositol monophosphatase, the putative therapeutic target for lithium. Brain Res. Rev. 22: 183–190.

    Article  PubMed  CAS  Google Scholar 

  • Barak, Y., Levine, J., Glasman, A., Elizur, A., and Belmaker, R.H., 1996, Inositol treatment of Alzheimer’s disease: A double blind, cross-over placebo controlled trial. Prog. Neuropsychopharmacol. Biol. Psychiatry 20: 729–735.

    Article  PubMed  CAS  Google Scholar 

  • Barkai, A., Dunner, D.L., Gross, H.A., Mayo, P., and Fieve, R.R., 1978, Reduced myo-inositol levels in cerebrospinal fluid from patients with affective disorder. Biol. Psychiatry 13: 65–72.

    PubMed  CAS  Google Scholar 

  • Benjamin, J., Levine, J., Fux, M., Aviv, A., Levy, D., and Belmaker, R.H., 1995, Double-blind, placebo-controlled, crossover trial of inositol treatment for panic disorder. Am. J. Psychiatry 152: 1084–1086.

    PubMed  CAS  Google Scholar 

  • Berridge, M.J., Downes, C.P., and Hanley, M.R., 1989, Neural and developmental actions of lithium: A unifying hypothesis. Cell 59: 411–419.

    Article  PubMed  CAS  Google Scholar 

  • Berridge, M.J., and Irvine, R.F., 1989, Inositol phosphates and cell signaling. Nature 341: 197–205.

    Article  PubMed  CAS  Google Scholar 

  • Berry, G.T., Buccafusca, R., Greer, J.J., and Eccleston, E., 2004, Phosphoinositide deficiency due to inositol depletion is not a mechanism of lithium action in brain. Mol. Genet. Metab. 82: 87–92.

    Article  PubMed  CAS  Google Scholar 

  • Brambilla, P., Stanley, J.A., Sassi, R.B., Nicoletti, M.A., Mallinger, A.G., Keshavan, M.S., and Soares, J.C., 2004, 1H MRS study of dorsolateral prefrontal cortex in healthy individuals before and after lithium administration. Neuropsychopharmacology 29: 1918–1924.

    Article  PubMed  CAS  Google Scholar 

  • Byun, S.M., and Jenness, R., 1981, Stereospecificity of L-myo-inositol 1-phosphate synthase for nicotinamide adenine dinucleotide. Biochemistry, 20: 5174–5177.

    Article  PubMed  CAS  Google Scholar 

  • Carman, G.M., and Henry, S.A., 1999, Phospholipid biosynthesis in the yeast Saccharomyces cerevisiae and interrelationship with other metabolic processes. Prog. Lipid Res. 38: 361–399.

    Article  PubMed  CAS  Google Scholar 

  • Chengappa, K.N., Levine, J., Gershon, S., Mallinger, A.G., Hardan, A., Vagnucci, A., Pollock, B., Luther, J., Buttenfield, J., Verfaille, S., and Kupfer, D.J., 2000, Inositol as an add-on treatment for bipolar depression. Bipolar Disord. 2: 47–55.

    Article  PubMed  CAS  Google Scholar 

  • Culbertson, M.R., Donahue, T.F., and Henry, S.A., 1976, Control of inositol biosynthesis in Saccharomyces cerevisiae; inositolphosphate synthetase mutants. J. Bacteriol. 126: 243–250.

    PubMed  CAS  Google Scholar 

  • Dyson, N., 1998, The regulation of E2F by pRB-family proteins. Gene Dev. 12: 2245–2262.

    PubMed  CAS  Google Scholar 

  • Eisenberg, F., Jr., 1967, D-myo-Inositol 1-phosphate as product of cyclization of glucose 6-phosphate and substrate for a specific phosphatase in rat testis. J. Biol. Chem. 242: 1375–1382.

    PubMed  CAS  Google Scholar 

  • Eisenberg, F., Jr., Bolden, A.H., and Loewus, F.A., 1964, Inositol formation by cyclization of glucose chain in rat testis. Biochem. Biophys. Res. Commun. 14: 419–424.

    Article  PubMed  Google Scholar 

  • Eisenberg, F, Jr., and Parthasarathy, R., 1984, Myo-inositol 1-phosphate. In: Bergmeyer, H.U. (ed.), Methods of Enzymatic Analysis, 3rd ed., Vol. 6. Verlag Chemie, Weinheim, pp. 371–375.

    Google Scholar 

  • Eisenberg, F. Jr., and Parthasarathy, R., 1987, Measurement of biosynthesis of myo-inositol from glucose 6-phosphate. Methods Enzymol. 14: 127–143.

    Google Scholar 

  • Fisher, S.K., Novak, J.E., and Agranoff, B.W., 2002, Inositol and higher inositol phosphates in neural tissues: Homeostasis, metabolism and functional significance. J. Neurochem. 82: 736–754.

    Article  PubMed  CAS  Google Scholar 

  • Frey, R., Metzler, D., Fischer, P., Heiden, A., Scharfetter, J., Moser, E., and Kasper, S. 1998, Myoinositol in depressive and healthy subjects determined by frontal 1H-magnetic resonance spectroscopy at 1.5 tesla. J. Psychaitr. Res., 32: 411–420.

    Article  CAS  Google Scholar 

  • Friedman, S.D., Dager, S.R., Parow, A., Hirashima, F., Demopulos, C., Stoll, A.L., Lyoo, I.K., Dunner, D.L., and Renshaw, P.F., 2004, Lithium and valproic acid treatment effects on brain chemistry in bipolar disorder. Biol. Psychiatry 56: 340–348.

    Article  PubMed  CAS  Google Scholar 

  • Fux, M., Benjamin, J., and Belmaker, R.H., 1999, Inositol versus placebo augmentation of serotonin reuptake inhibitors in the treatment of obsessive-compulsive disorder: A double-blind cross-over study. Int. J Neuropsychopharmacol. 2: 193–195.

    Article  PubMed  CAS  Google Scholar 

  • Fux, M., Levine, J., Aviv, A., and Belmaker, R.H., 1996, Inositol treatment of obsessive-compulsive disorder. Am. J. Psychiatry 153: 1219–1221.

    PubMed  CAS  Google Scholar 

  • Gelber, D., Levine, J., and Belmaker, R.H., 2001, Effect of inositol on bulimia nervosa and binge eating. Int. J. Eat. Disord. 29: 345–348.

    Article  PubMed  CAS  Google Scholar 

  • Greenberg, M.L., Reiner, B., and Henry, S.A., 1982, Regulatory mutations of inositol biosynthesis in yeast: Isolation of inositol-excreting mutants. Genetics, 100: 19–33.

    PubMed  CAS  Google Scholar 

  • Groenen, P.M., Merkus, H.M., Sweep, F.C., Wevers, R.A., Janssen, F.S., and Steegers-Theunissen, R.P., 2003, Kinetics of myo-inositol loading in women of reproductive age. Ann. Clin. Biochem. 40: 79–85.

    Article  PubMed  CAS  Google Scholar 

  • Guan, G., Dai, P., and Shechter, I., 2003, cDNA cloning and gene expression analysis of human myo-inositol 1-phosphate synthase. Arch. Biochem. Biophys. 417: 251–259.

    Article  PubMed  CAS  Google Scholar 

  • Hallcher, L.M., and Sherman, W.R., 1980, The effects of the lithium ion and other agents on the activity of myo-inositol 1-phosphatase from bovine brain. J. Biol. Chem. 255: 10896–10901.

    PubMed  CAS  Google Scholar 

  • Harwood, A.J., 2005, Lithium and bipolar mood disorder: The inositol-depletion hypothesis revisited. Mol. Psychiatry 10: 117–126.

    Article  PubMed  CAS  Google Scholar 

  • Hasegawa, R., and Eisenberg, F. Jr., 1981, Selective hormonal control of myo-inositol biosynthesis in reproductive organs and liver of the male rat. Proc. Natl. Acad. Sci. U.S.A. 78: 4863–4866.

    Article  PubMed  CAS  Google Scholar 

  • Hirsch, J.P., and Henry, S.A., 1986, Expression of the Saccharomyces cerevisiae inositol-1-phosphate synthase (INO1) gene is regulated by factors that affect phospholipid synthesis. Mol. Cell. Biol. 6: 3320–3328.

    PubMed  CAS  Google Scholar 

  • Honchar, M.P., Ackerman, K.E., and Sherman, W.R., 1989, Chronically administered lithium alters neither myo-inositol monophosphatase activity nor phosphoinositide levels in rat brain. J. Neurochem. 53: 590–594.

    PubMed  CAS  Google Scholar 

  • Jin, X., Foley, K.M., and Geiger, J.H., 2004, The structure of the 1L-myo-inositol-1-phosphate synthase-NAD-2-deoxy-D-glucitol 6-(E)-vinylhomophosphonate complex demands a revision of the enzyme mechanism. J. Biol. Chem. 279: 13889–13895.

    Article  PubMed  CAS  Google Scholar 

  • Jin, X., and Geiger, J.H., 2004, Structures of NAD+-and NADH-bound 1-L-myo-inositol 1phosphate synthase. Acta. Crystallogr. D. Biol. Crystallogr. 59: 1154–1164.

    Article  Google Scholar 

  • Jiranek, V., Graves, J.A., and Henry, S.A., 1998, Pleiotropic effects of the opi1 regulatory mutation of yeast: Its effects on growth and on phospholipid and inositol metabolism. Microbiology 144: 2739–2748.

    Article  PubMed  CAS  Google Scholar 

  • Ju, S., Shaltiel, G., Shamir, A., Agam, G., and Greenberg, M.L., 2004, Human 1-D-myo-inositol-3-phosphate synthase is functional in yeast. J. Biol. Chem. 279: 21759–21765.

    Article  PubMed  CAS  Google Scholar 

  • Kadonaga, J.T., Jones, K.A., and Tjian, R., 1986, Promoter-specific activation of RNA polymerase II transcription by Sp1. Trends Biochem. Sci. 11: 20–23.

    Article  CAS  Google Scholar 

  • Kaplan, Z., Amir, M., Swartz, M., and Levine, J., 1996, Inositol treatment of post-traumatic stress disorder. Anxiety 2: 51–52.

    Article  PubMed  CAS  Google Scholar 

  • Kel, A.E., Kel-Margoulis, O.V., Farnham, P.J., Bartley, S.M., Wingender, E., and Zhang, M.Q., 2001, Computer-assisted identification of cell cycle-related genes: New targets for E2F transcription factors. J. Mol. Biol. 309: 99–120.

    Article  PubMed  CAS  Google Scholar 

  • Klig, L.S., and Henry, S.A., 1984, Isolation of the yeast INO1 gene: Located on an autonomously replicating plasmid, the gene is fully regulated. Proc. Natl. Acad. Sci. U.S.A. 82: 3816–3820.

    Article  Google Scholar 

  • Levine, J., Aviram, A., Holan, A., Ring, A., Barak, Y., and Belmaker, R.H., 1997, Inositol treatment of autism. J. Neural Transm. 104: 307–310.

    Article  PubMed  CAS  Google Scholar 

  • Levine, J., Barak, Y., Gonzales, M., Szor, H., Elizur, A., Kofman, O., and Belmaker, R.H., 1995b, Double-blind, controlled trial of inositol treatment of depression. Am. J. Psychiatry 152: 792–794.

    PubMed  CAS  Google Scholar 

  • Levine, J., Kurtzman, L., Rapport, A., Zimmerman, J., Bersudsky, Y., Shapiro, J., Belmaker, R.H., and Agam, G., 1996, CSF inositol does not predict antidepressant response to inositol. J. Neural Transm. 103: 1457–1462.

    Article  PubMed  CAS  Google Scholar 

  • Levine, J., Rapaport, A., Lev, L., Bersudsky, Y., Kofman, O., Belmaker, R.H., Shapiro, J., and Agam, G., 1993b, Inositol treatment raises CSF inositol levels. Brain Res. 627: 168–170.

    Article  PubMed  CAS  Google Scholar 

  • Levine, J., Ring, A., Barak, Y., Elizur, A., and Belmaker, R.H., 1995a, Inositol may worsen attention deficit disorder with hyperactivity. Human Psychopharmacol. 10: 481–484.

    Article  CAS  Google Scholar 

  • Levine, J., Umansky, R., Ezrielev, G., and Belmaker, R.H., 1993a, Lack of effect of inositol treatment in chronic schizophrenia. Biol. Psychiatry 33: 673–675.

    Article  PubMed  CAS  Google Scholar 

  • Loewus, M.W., Loewus, F.A., Brillinger, G.U., Otsuka, H., and Floss, H.G., 1980, Stereochemistry of the myo-inositol-1-phosphate synthase reaction. J. Biol. Chem. 255: 11710–11712.

    PubMed  CAS  Google Scholar 

  • Loewy, B.S., and Henry, S.A., 1984, The INO2 and INO4 loci of Saccharomyces cerevisiae are pleiotropic regulatory genes. Mol. Cell Biol. 4: 2479–2485.

    PubMed  CAS  Google Scholar 

  • Lopes, J.M., and Henry, S.A., 1991, Interaction of trans and cis regulatory elements in the INO1 promoter of Saccharomyces cerevisiae. Nucleic Acids Res. 19: 3987–3994.

    PubMed  CAS  Google Scholar 

  • Maeda, T., and Eisenberg, F. Jr., 1980, Purification, structure, and catalytic properties of L-myo-inositol 1-phosphate synthase from rat testis. J. Biol. Chem. 255: 8458–8464.

    PubMed  CAS  Google Scholar 

  • Majerus, P.W., Kisseleva, M.V., and Norris, F.A., 1999, The role of phosphatases in inositol signaling reactions. J. Biol. Chem. 274: 10669–10672.

    Article  PubMed  CAS  Google Scholar 

  • Majumder, A.L., Chatterjee, A., Dastidar, K.G., and Majee, M., 2003, Diversification and evolution of L-myo-inositol 1-phosphate synthase. FEBS Lett. 553: 3–10.

    Article  PubMed  CAS  Google Scholar 

  • Majumder, A.L., Johnson, M.D., and Henry, S.A., 1997, 1L-myo-inositol-1-phosphate synthase, Biochim. Biophys. Acta, 1348: 245–256.

    CAS  Google Scholar 

  • Mauck, L.A., Wong, Y.H., and Sherman, W.R., 1980, L-myo-Inositol-1-phosphate synthase from bovine testis: Purification to homogeneity and partial characterization. Biochemistry 19: 3623–3629.

    Article  PubMed  CAS  Google Scholar 

  • McCauley, J.L., Li, C., Jiang, L., Olson, L.M., Crockett, G., Gainer, K., Folstein, S.E., Haines, J.L., and Sutcliffe, J.S., 2005, Genome-wide and ordered-subset linkage analyses provide support for autism loci on 17q and 19p with evidence of phenotypic and interlocus genetic correlates. BMC. Med. Genet. 6: 1–15.

    Article  PubMed  CAS  Google Scholar 

  • McDougle, C.J., Naylor, S.T., Cohen, D.J., Volkmar, F.R., Heninger, G.R., and Price, L.H., 1996, A double-blind, placebo-controlled study of fluvoxamine in adults with autistic disorder. Arch. Gen. Psychiatry, 53: 1001–1008.

    PubMed  CAS  Google Scholar 

  • Migaud, M.E., and Frost, J.W., 1995, Inhibition of myo-inositol 1-phosphate synthase reaction by a reaction coordinate intermediate. J. Am. Chem. Soc. 117: 5154–5155.

    Article  CAS  Google Scholar 

  • Naccarato, W.F., Ray, R.E., and Wells, W.W., 1974, Biosynthesis of myo-inositol in rat mammary gland. Isolation and properties of the enzymes. Arch. Biochem. Biophys. 162: 194–201.

    Article  Google Scholar 

  • Nemets, B., Talesnick, B., Belmaker, R.H., and Levine, J., 2002, Myo-inositol has no beneficial effect on premenstrual dysphoric disorder. World J. Biol. Psychiatry 3: 147–149.

    Article  PubMed  Google Scholar 

  • Norman, R.A., McAlister, M.S., Murray-Rust, J., Movahedzadeh, F., Stoker, N.G., and McDonald, N.Q., 2002, Crystal structure of inositol 1-phosphate synthase from Mycobacterium tuberculosis, a key enzyme in phosphatidylinositol synthesis. Structure 10: 393–402.

    Article  PubMed  CAS  Google Scholar 

  • Pacheco, M.A., and Jope, R.S., 1996, Phosphoinositide signaling in human brain. Prog. Neurobiol. 50: 255–273.

    Article  PubMed  CAS  Google Scholar 

  • Palatnik, A., Frolov, K., Fux, M., and Benjamin, J., 2001, Double blind, controlled, crossover trial of inositol versus fluvoxamine for the treatment of panic disorder. J. Clin. Psycho-pharmacol. 21: 335–339.

    Article  CAS  Google Scholar 

  • Parthasarathy, R., and Eisenberg, F. Jr., 1986, The inositol phopholipids: A stereochemical view of biological activity. Biochem. J. 235: 313–322.

    PubMed  CAS  Google Scholar 

  • Parthasarathy, R., and Eisenberg, F. Jr., 1991, Inositol Phosphates and Derivatives: Synthesis, Biochemistry and Therapeutic Potential. American Chemical Society, Washington, DC, pp. 1–19.

    Google Scholar 

  • Parthasarathy, R., Parthasarathy, L., and Vadnal, R.E., 1993, Identification of phosphatidyl inositol tris-phosphate in rat brain. In: Fain, J. (ed.), Methods in Neurosciences, Vol. 18. Academic Press, N.Y., pp. 113–124.

    Google Scholar 

  • Parthasarathy, L., Vadnal, R.E., Parthasarathy, R., and Devi, C.S.S., 1994, Biochemical and molecular properties of lithium-sensitive myo-inositol monophosphatase. Life Sci. 54: 1127–1142.

    Article  PubMed  CAS  Google Scholar 

  • Renshaw, P.F., Joseph, N.E., and Leigh, J.S., 1986, Chronic dietary lithium induces increased levels of myo-inositol 1-phosphatase activity in rat cerebral cortex homogenates. Brain Res. 380: 401–404.

    Article  PubMed  CAS  Google Scholar 

  • Rivera-Gonzalez, R., Petersen, D.N., Tkalcevic, G., Thompson, D.D., and Brown, T.A., 1998, Estrogen-induced genes in the uterus of ovariectomized rats and their regulation by droloxifene and tamoxifen. J. Steroid Biochem. Mol. Biol. 64: 13–24.

    Article  PubMed  CAS  Google Scholar 

  • Saiardi, A., Bhandari, R., Resnick, A.C., Snowman, A.M., and Snyder, S.H., 2004, Phosphorylation of proteins by inositol pyrophosphates. Science 306: 2101–2105.

    Article  PubMed  CAS  Google Scholar 

  • Seelan, R.S., Parthasarathy, L., and Parthasarathy, R., 2004, E2F1 regulation of the human myoinositol 1-phosphate synthase (ISYNA1) gene promoter. Arch. Biochem. Biophys. 431: 95–106.

    Article  PubMed  CAS  Google Scholar 

  • Shaltiel, G, Shamir, A., Shapiro, J., Ding, D., Dalton, E., Bialer, M., Harwood, A.J., Belmaker, R.H., Greenberg, M.L. and Agam, G., 2004, Valproate decreases inositol biosynthesis. Biol Psychiatry, 56: 868–874.

    Article  PubMed  CAS  Google Scholar 

  • Shamir, A., Shaltiel, G., Greenberg, M.L., Belmaker, R.H., and Agam, G, 2003, The effect of lithium on expression of genes for inositol biosynthetic enzymes in mouse hippocampus: A comparison with the yeast model. Brain Res. Mol. Brain Res. 115: 104–110 (Erratum in Brain Res. Mol. Brain Res, 2004, 123: 137).

    Article  PubMed  CAS  Google Scholar 

  • Sherman, W.R., Leavitt, A.L., Honchar, M.P., Hallcher, L.M., Packman, P.M., and Phillips, B.E., 1981b, Evidence that lithium alters phosphoinositide metabolism: Chronic administration elevates primarily D-myo-inositol-1-phosphate in cerebral cortex of the rat. J. Neurochem. 36: 1947–1951.

    PubMed  CAS  Google Scholar 

  • Sherman, W.R., Loewus, M.W., Pina, M.Z., and Wong, Y.H., 1981a, Studies on myo-inositol-1-phosphate from Lilium longiflorum pollen, Neurospora crassa and bovine testis. Further evidence that a classical aldolase step is not utilized. Biochim. Biophys. Acta. 660: 299–305.

    PubMed  CAS  Google Scholar 

  • Stein, A.J., and Geiger, J.H., 2000, Structural studies of MIP synthase. Acta. Crystallogr. D. Biol. Crystallogr. 56: 348–350.

    Article  PubMed  CAS  Google Scholar 

  • Stein, A.J., and Geiger, J.H., 2002, The crystal structure and mechanism of 1-L-myo-inositol-1-phosphate synthase. J. Biol. Chem. 277: 9484–9491.

    Article  PubMed  CAS  Google Scholar 

  • Suske, G., 1999, The Sp-family of transcription factors. Gene 238: 291–300.

    Article  PubMed  CAS  Google Scholar 

  • Tao, Y., Kassatly, R.F., Cress, W.D., and Horowitz, J.M., 1997, Subunit composition determines E2F DNA-binding site specificity. Mol. Cell. Biol. 17: 6994–7007.

    PubMed  CAS  Google Scholar 

  • Thurston, J.H., Sherman, W.R., Hauhart, R.E., and Kloepper, R.F., 1989, myo-inositol: A newly identified non-nitrogenous osmoregulatory molecule in mammalian brain. Pediatr. Res. 26: 482–485.

    PubMed  CAS  Google Scholar 

  • Tsunoda, T., and Takagi, T., 1999, Estimating transcription factor bindability on DNA. Bioinformatics 15: 622–630.

    Article  PubMed  CAS  Google Scholar 

  • Vadnal, R.E., Parthasarathy, L., and Parthasarathy, R., 1997, Role of inositol in psychiatric disorderss: Basic and clinical aspects. CNS Drugs 7: 6–16.

    Article  CAS  Google Scholar 

  • Wells, J., Graveel, C.R., Bartley, S.J., Madore, S.J., and Farnham, P.J., 2002, The identification of E2F1-specific target genes. Proc. Natl. Acad. Sci. U.S.A. 99: 3890–3895.

    Article  PubMed  CAS  Google Scholar 

  • Whitworth, P., and Kendall, D.A., 1989, Effects of lithium on inositol phospholipid hydrolysis and inhibition of dopamine D1 receptor-mediated cyclic AMP formation by carbachol in rat brain slices. J. Neurochem. 53: 536–541.

    PubMed  CAS  Google Scholar 

  • Whiting, P.H., Palmano, K.P., and Hawthorne, J.N., 1979, Enzymes of myo-inositol and inositol lipid metabolism in rats with streptozotocin-induced diabetes. Biochem. J. 179: 549–553.

    PubMed  CAS  Google Scholar 

  • Wong, Y.H., and Sherman, W.R., 1980, Anomeric and other substrate specificity studies with myo-inositol 1-P synthase. J. Biol. Chem. 260: 11083–11090.

    Google Scholar 

  • Yildiz, A., Demopulos, C.M., Moore, C.M., Renshaw, P.F., and Sachs, G.S., 2001, Effect of lithium on phosphoinositide metabolism in human brain: A proton decoupled (31)P magnetic resonance spectroscopy study. Biol. Psychiatry 50: 3–7.

    Article  PubMed  CAS  Google Scholar 

  • York, J.D., and Hunter, T., 2004, Signal transduction: Unexpected mediators of protein phosphorylation. Science 306: 2053–2055.

    Article  PubMed  CAS  Google Scholar 

  • Zeiner, M., and Gehring, U., 1994, Cloning of 5′ cDNA regions by inverse PCR. Biotechniques 17: 1052–1054.

    Google Scholar 

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Parthasarathy, L.K., Ratnam, L., Seelan, S., Tobias, C., Casanova, M.F., Parthasarathy, R.N. (2006). Mammalian Inositol 3-phosphate Synthase: Its Role in the Biosynthesis of Brain Inositol and its Clinical Use as a Psychoactive Agent. In: Majumder, A.L., Biswas, B.B. (eds) Biology of Inositols and Phosphoinositides. Subcellular Biochemistry, vol 39. Springer, Boston, MA . https://doi.org/10.1007/0-387-27600-9_12

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