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Anticancer Gene Therapy by in Vivo DNA Electrotransfer of MBD2 Antisense

  • Chapter
DNA Methylation and Cancer Therapy

Part of the book series: Medical Intelligence Unit ((MIUN))

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Abstract

Harnessing the full therapeutic potential of DNA methylation machinery proteins would require efficient techniques of introducing either anti sense, iRNA or expression vectors into tumors in vivo. Efficient techniques for introducing DNA in vivo are also required for target validation. This chapter discusses the electrotransfer of introducing DNA in vivo and its use in validation of MBD2 as anticancer target as well as its potential as an anticancer gene therapy.

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  1. Unite de Pharmacologie Chimique et Genetique, Universite Ren Descartes, Paris, France

    Pascal Bigey & Daniel Scherman

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Bigey, P., Scherman, D. (2005). Anticancer Gene Therapy by in Vivo DNA Electrotransfer of MBD2 Antisense. In: DNA Methylation and Cancer Therapy. Medical Intelligence Unit. Springer, Boston, MA. https://doi.org/10.1007/0-387-27443-X_16

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