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Regulation of DNA Methyltransferases in Cancer

  • Chapter
DNA Methylation and Cancer Therapy

Part of the book series: Medical Intelligence Unit ((MIUN))

Abstract

The DNA methyltransferases (DNMTs) are critical proteins involved in establishing proper control of epigenetic information. They are responsible for maintaining the cell’s methylation pattern, as well for transcriptional repression through both methylation dependent and independent mechanisms. It is therefore fitting that the cell has evolved a number of layers of regulation to manage the appropriate expression of the DNMTs. While transcriptional control is the major player in regulation of DNMT1 by signaling pathways, post-transcriptional mechanisms appear to be critical for regulation during cell cycle progression and differentiation. In addition, regulatory interactions between DNMT1 and proteins involved in replication and cell cycle progression, as well as between all three DNMTs, have recently been elucidated. This review will discuss cellular processes in which these various mechanisms are involved, and provide suggestions as to how misregulation at these levels might lead to the development of certain pathologies.

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  1. Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada

    Nancy Detich & Moshe Szyf Ph.D.

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Detich, N., Szyf, M. (2005). Regulation of DNA Methyltransferases in Cancer. In: DNA Methylation and Cancer Therapy. Medical Intelligence Unit. Springer, Boston, MA. https://doi.org/10.1007/0-387-27443-X_10

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