Skip to main content

Twinkle Twinkle Little Spark: Out of Tune Potassium Channels

  • Chapter
Pumps, Transporters, and Ion Channels

Part of the book series: Series of the Centro de Estudios Científicos ((SCEC))

  • 672 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

5. References

  • Benham, C. D. and Bolton T. B, 1986, Spontaneous transient outward currents in single visceral and vascular smooth muscle cells of the rabbit, Journal of Physiology (Lond), 381:385–406.

    Google Scholar 

  • Brayden, J.E. and Nelson, M.T., 1992, Regulation of arterial tone by activation of calcium-dependent potassium channels, Science, 256:532–535.

    Article  ADS  Google Scholar 

  • Brenner R., Perez G.J., Bonev A.D., Eckman D.M., Kosek J.C., Wiler S.W., Patterson A.J., Nelson M.T., and Aldrich R.W, 2000, Vasoregulation by the betal subunit of the calcium-activated potassium channel, Nature, 407:870–876.

    Article  ADS  Google Scholar 

  • Cecchi, X., Alvarez, O., & Wolff, D., 1986, Characterization of a calcium-activated potassium channel from rabbit intestinal smooth muscle incorporated into planar bilayers, Journal of Membrane Biology, 91:11–18.

    Article  Google Scholar 

  • Cox, D. H. and Aldrich, R. W., 2000, Role of the β1 subunit in large-conductance Ca2+-activated K+ channel gating energetics, Mechanisms of enhanced Ca2+ sensitivity, Journal of General Physiology 116:411–432.

    Article  Google Scholar 

  • Dick, G. M., and Sanders, K. M., 2001, (Xeno) estrogen sensitivity of smooth muscle BK channels conferred by the regulatory beta 1 subunit: a study of beta 1 knockout mice, Journal of Biological Chemistry, 276:44835–44840.

    Article  Google Scholar 

  • Dworetzky, S.I., Boissard C.G., Lum-Ragan J.T., McKay M.C., Post-Munson D.J., Trojnacki J.T., Chang C.P., and Gribkoff V.K, 1996, Phenotypic Alteration of a Human BK (hSlo) Channel by hSlobeta Subunit Coexpression: Changes in Blocker Sensitivity, Activation/Relaxation and Inactivation Kinetics, and Protein Kinase A Modulation, Journal of Neuroscience, 16:4543–4550.

    Google Scholar 

  • Fay F.S. 1995, Calcium sparks in vascular smooth muscle: relaxation regulators, Science, 270:588–589.

    Article  ADS  Google Scholar 

  • Garcia-Calvo, M., Knaus H. G., McManus O. B., Giangiacomo K. M., Kaczorowski G. J, and Garcia M. L., 1994, Purification and reconstitution of the high-conductance, calcium-activated potassium channel from tracheal smooth muscle, Journal of Biological Chemistry, 269:676–682.

    Google Scholar 

  • Jaggar, J. H., Porter V. A., Lederer W. J., and Nelson M. T., 2000, Calcium sparks in smooth muscle, American Journal of Physiology, Cell Physiology, 278: C235–C256.

    Google Scholar 

  • Knot, H.J., Standen, N.B., and Nelson, M.T., 1998, Ryanodine receptors regulate arterial diameter and wall [Ca2+] in cerebral arteries of rat via Ca2+-dependent K+ channels, Journal of Physiology (Lond) 508:211–221.

    Article  Google Scholar 

  • Latorre, R., Vergara, C, & Hidalgo, C., 1982, Reconstitution in planar lipid bilayers of a Ca2+-dependent K+ channel from transverse tubule membranes isolated from rabbit skeletal muscle, Proceedings of the National Academy of Science U.S.A., 79:805–809.

    Article  ADS  Google Scholar 

  • McManus, O.B. Helms, L. M., Pallanck, L., Ganetzky, B., Swanson, R., and Leonard, R. J., 1995, Functional role of the beta subunit of high conductance calcium-activated potassium channels, Neuron, 14:645–650.

    Article  Google Scholar 

  • Meera, P., Wallner, M., Jiang, Z. and Toro, L., 1996, A calcium switch for the functional coupling between alpha (hslo) and beta subunits (KV,Ca beta) of maxi K channels, FEBS Letters, 382:84–88.

    Article  Google Scholar 

  • Nelson M.T., Cheng H., Rubart M., Santana L.F., Bonev A.D., Knot H.J., Lederer W.J., 1995, Relaxation of arterial smooth muscle by calcium sparks, Science, 270:633–7.

    Article  ADS  Google Scholar 

  • Nimigean, C. M. and Magleby K.L., 2000, Functional coupling of the β subunit to the large conductance Ca2+-activated K+ channel in the absence of Ca2+, Increased Ca2+ sensitivity from a Ca2+ independent mechanism, Journal of General Physiology, 115:719–734.

    Article  Google Scholar 

  • Perez, G.J., Bonev, A.D., Patlak, J.B. and Nelson, M.T., 1999, Functional coupling of ryanodine receptors to KCa channels in smooth muscle cells from rat cerebral arteries, Journal of General Physiology, 113:229–238.

    Article  Google Scholar 

  • Standen, N. Cardiovascular biology: Tuning channels for blood pressure, Nature 407, 845–848 (2000).

    Article  ADS  Google Scholar 

  • Tanaka, Y., Meera, P., Song, M., Knaus, H.G. and Toro, L. Molecular constituents of maxi KCa channels in human coronary smooth muscle: predominant alpha + beta subunit complexes, J Physiol (Lond) 502, 545–557 (1997).

    Article  Google Scholar 

  • Toro, L., Ramos-Franco, J., & Stefani, E., 1990, GTP-dependent regulation of myometrial KCa channels incorporated into lipid bilayers, Journal of General Physiology 96, 373–394.

    Article  Google Scholar 

  • Tseng-Crank, J., N. Godinot, T. E. Johansen, P. K. Ahring, D. Strobaek, R. Mertz, C. D. Foster, S. P. Olesen, and P. H. Reinhart, Cloning, expression, and distribution of a Ca(2+)-activated K+ channel beta-subunit from human brain, Proc. Natl. Acad. Sci. 93, 9200–9205 (1996).

    Article  ADS  Google Scholar 

  • Valverde M., Rojas. P. Amigo, J. Cosmelli, D. Orio, P., Bahamonde M. I., Mann, G. E., Vergara, C. and Latorre, R., Acute Activation of Maxi-K channels (hSlo) by estradiol binding to the β subunit, Science 285, 1929–1931 (1999).

    Article  Google Scholar 

  • Wallner, M., P. Meera, M. Ottolia, G. J. Kaczorowski, R. Latorre, M. L. Garcia, E. Stefani, and L. Toro. Characterization of and modulation by a beta-subunit of a human maxi KCa channel cloned from myometrium, Receptors, Channels 3, 185–199 (1995).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2005 Kluwer Academic/Plenum Publishers, New York

About this chapter

Cite this chapter

Pérez, G.J. (2005). Twinkle Twinkle Little Spark: Out of Tune Potassium Channels. In: Sepúlveda, F.V., Bezanilla, F. (eds) Pumps, Transporters, and Ion Channels. Series of the Centro de Estudios Científicos. Springer, Boston, MA. https://doi.org/10.1007/0-387-27424-3_15

Download citation

Publish with us

Policies and ethics