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Zinc Finger Proteins pp 261–264Cite as

The Zip Family of Zinc Transporters

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Part of the book series: Molecular Biology Intelligence Unit ((MBIU))

Abstract

The ZIP family of transporters plays important roles in supplying zinc to metalloproteins. These transporters are found in organisms at all phylogenetic levels including bacteria, fungi, plants, insects, and mammals. They have many conserved sequence elements and most have eight likely transmembrane domains with similar predicted topologies. Intracellular zinc homeostasis is facilitated by both transcriptional and post-transcriptional control mechanisms that regulate ZIP transporter activity. These systems work in concert to provide a constant supply of zinc in the face of changing extracellular levels and limit overaccumulation of this potentially toxic metal.

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Author information

Authors and Affiliations

  1. Departments of Nutritional Sciences and Biochemistry, University of Missouri, Columbia, Missouri, USA

    David J. Eide

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  1. David J. Eide
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Editor information

Editors and Affiliations

  1. Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA

    Shiro Iuchi

  2. Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

    Natalie Kuldell

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© 2005 Landes Bioscience/Eurekah.com and Kluwer Academic/Plenum Publishers

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Eide, D.J. (2005). The Zip Family of Zinc Transporters. In: Iuchi, S., Kuldell, N. (eds) Zinc Finger Proteins. Molecular Biology Intelligence Unit. Springer, Boston, MA. https://doi.org/10.1007/0-387-27421-9_35

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