Abstract
In many developmental systems, nuclear regulators have been implicated in coupling key events in gene expression with specific cell fate and lineage decisions. In the hemo-lymphoid system, the Ikaros gene family of zinc finger DNA binding factors controls lymphocyte specification and homeostasis from the hemopoietic stem cell (HSC) throughout development. The dependence of hemo-lymphoid differentiation on Ikaros DNA binding activity together with the presence of Ikaros proteins within higher order chromatin remodeling complexes supports the hypothesis that Ikaros plays a key role in the lineage-specific remodeling of chromatin. Association of Ikaros and its remodeling partners with the chromatin of key lineage-specific genes, and the dependence of these genes on Ikaros complexes for their expression supports this hypothesis and provides unique paradigms to study chromatin regulation of differentiation.
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Gómez-del Arco, P., Naito, T., Seavitt, J., Yoshida, T., Williams, C., Georgopoulos, K. (2005). The Role of the Ikaros Gene Family in Lymphocyte Development. In: Iuchi, S., Kuldell, N. (eds) Zinc Finger Proteins. Molecular Biology Intelligence Unit. Springer, Boston, MA. https://doi.org/10.1007/0-387-27421-9_27
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DOI: https://doi.org/10.1007/0-387-27421-9_27
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-306-48229-8
Online ISBN: 978-0-387-27421-8
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