Abstract
Wilms tumor suppressor gene product WT1 is a Cys2His2 (C2H2) zinc finger protein, one of the largest protein families in higher eukaryotes. Since the cloning of WT1 in 1990, we have learned a great deal about the functions of WT1. Now, even greater molecular details of WT1 are beginning to emerge with a possibility of the unexpected role of WT1 in the post-transcriptional processes. This chapter does not include all aspects of WT1, but is intended to focus on and highlight the biological function of WT1 (for detailed reviews see refs. 1-4). The chapter consists largely of two parts, the biochemical characterization of WT1 and the genetics of WT1 in both the human and the mouse, and ends with future perspectives on WT1 research.
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Lee, S.B., Li, H., Kim, HS. (2005). The Role of WT1 in Development and Disease. In: Iuchi, S., Kuldell, N. (eds) Zinc Finger Proteins. Molecular Biology Intelligence Unit. Springer, Boston, MA. https://doi.org/10.1007/0-387-27421-9_24
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DOI: https://doi.org/10.1007/0-387-27421-9_24
Publisher Name: Springer, Boston, MA
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