Summary
Hopefully, the reader will be able to see the interconnections between nonlinear mixed effects models and linear mixed effects modeling, nonlinear modeling, and linear modeling. The algorithms behind nonlinear mixed effects models are certainly more complex than any of the other model types examined, but the basic ideas behind developing PopPK models are the same as those that were developed using the other classes of models. This chapter has just provided some of the theory behind PopPK models. The next chapter will deal with practical issues in PopPK modeling and the chapter after that will present case studies in PopPK modeling.
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(2006). Nonlinear Mixed Effects Models: Theory. In: Pharmacokinetic-Pharmacodynamic Modeling and Simulation. Springer, Boston, MA. https://doi.org/10.1007/0-387-27199-6_7
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DOI: https://doi.org/10.1007/0-387-27199-6_7
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-387-27197-2
Online ISBN: 978-0-387-27199-6
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