Chemosensory Control of the Respiratory Function
Respiratory drive is sensitive to small changes in arterial PO2 and PCO2 which are sensed by the peripheral chemoreceptors located within the carotid and aortic bodies and by central chemoreceptors localised within the brain (Gonzalez et al., 1994; Daly, 1997; Nattie, 1999; Prabhakar, 2000). In adult mammals type I (glomus) cells of the carotid body are the primary peripheral chemosensitive elements which detect changes in arterial PO2 (Gonzalez et al., 1994; Prabhakar, 2000) and transmit this information to the afferent nerve fibres of the carotid sinus nerve, which in turn relays to the brainstem respiratory centres to produce adaptive changes in ventilation. Levels of PCO2 are monitored predominantly by the central chemoreceptors localised within the medulla oblongata (primarily at, or in close proximity to, the ventral medullary surface [Loeschcke, 1982]), as up to 80% of the CO2-evoked ventilatory response is mediated by the action of CO2 at the brainstem chemosensitive sites (Heeringa et al., 1979).
KeywordsCarotid Body Ventilatory Response Carotid Sinus Nerve Central Chemoreceptor Inspiratory Neurone
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- Cockayne, D., Dunn, P.M., Burnstock, G., and Ford, A., 2002, Generation and electrophysiological characterization of P2X2 and P2X2/P2X3 knockout (KO) mice. Neurosci. Abstr. 52: 12.Google Scholar
- Cockayne, D., Hamilton, S.G., Zhu, Q.M., Dunn, P.M., Zhong, Y., Novakovic, S., Malmberg, A.B., Cain, G., Berson, A., Kassotakis, L., Hedley, L., Lachnit, W.G., Burnstock, G., McMahon, S.B., and Ford, A.P., 2000, Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice. Nature 407: 1011–1015.CrossRefPubMedGoogle Scholar
- Daly, M. DeB., 1997, Peripheral arterial chemoreception and respiratory-cardiovascular integration. In Monograph for the Physiological Society. Oxford University Press, Oxford.Google Scholar
- Yao, S.T., Barden, J.A., Finkelstein, D.I., Bennett, M.R., and Lawrence, A.J., 2000, Comparative study on the distribution patterns of P2X1-P2X6 receptor immunoreactivity in the brainstem of the rat and the common marmoset (Callithrix jacchus): association with catecholamine cell groups. J. Comp. Neurol. 427: 485–507.CrossRefPubMedGoogle Scholar
- Yao, S.T., Gourine, A.V., Spyer, K.M., Barden, J.A., and Lawrence, A.J., 2003, Localisation of P2X2 receptor subunit immunoreactivity on nitric oxide synthase expressing neurones in the brain stem and hypothalamus of the rat: a fluorescence immunohistochemical study. Neuroscience 121:411–419.CrossRefPubMedGoogle Scholar