Advertisement

Effect of Progressive Hypoxia with Moderate Hypercapnia on Ventilatory vs. Respiratory Sensation Responses in Humans

  • Yoshikazu Sakakibara
  • Atsuko Masuda
  • Toshio Kobayashi
  • Shigeru Masuyama
  • Yoshiyuki Honda
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 551)

Abstract

Ventilatory response to CO2 combined with hypoxic stimulation has been well documented as exhibiting a positive interaction between the two stimuli in humans1, and in cats2,3. Furthermore, Mohan and Duffin4 examined the effect of hypoxia on ventilatory response to CO2 using a modified Read’s rebreathing method, covering wide range of CO2 including hypocapnic region following prior hyperventilation.

Keywords

Visual Analog Scale Ventilatory Response Chemical Stimulus Hypoxic Ventilatory Response Respiratory Sensation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    M. Nielsen and H. Smith, Studies on the regulation of respiration in acute hypoxia. Act Physiol. 24, 293–313 (1952).CrossRefGoogle Scholar
  2. 2.
    T. F. Hornbein, Z. Griffo, A. Roos, Quantification of chemoreceptor activity: intercation of hypoxia and hypercapnia. J. Neurophysiol. 24, 561–568 (1961).PubMedGoogle Scholar
  3. 3.
    R.S. Fitzgerald, D.C. Parks, Effect of hypoxia on carotid chemoreceptor response to carbon dioxide in cats, Respir. Physiol. 12, 218–229 (1971).CrossRefPubMedGoogle Scholar
  4. 4.
    R. Mohan and J. Duffin, The effect of hypoxia on the ventilatory response to carbon dioxide in man. Respir. physiol. 108, 101–115 (1997).CrossRefPubMedGoogle Scholar
  5. 5.
    R. B. Banzett, R. W. Lansing, K. C. Evans, and S. A. Shea, Stimulus-response characteristics of CO2-induced air hunger in normal subjects. Respir. Physiol. 103, 19–31 (1996).CrossRefPubMedGoogle Scholar
  6. 6.
    S. H. Moosavi, E. Golestanian, A. P. Binks, R. W. Lansing, R. Brown, and R. B. Banzett, Hypoxic and hypercapnic drives to breathe generate equivalent levels of air hunger in humans. J Appl. Physiol. 94(1), 141–154 (2003).PubMedGoogle Scholar
  7. 7.
    A. Masuda, Y. Ohyabu, T. Kobayashi, C. Yoshino, Y. Sakakibara, T. Komatsu, and Y. Honda, Lack of positive interaction between CO2 and hypoxic stimulation for Pco2-VAS response slope in humans, Respir. Physiol. 121, 173–181 (2001).CrossRefGoogle Scholar
  8. 8.
    L. Adams, R. Lane, A. Shea, A. Cockcroft, and A. Guz, Breathlessness during different forms of ventilatory stimulation: a study of mechanism in normal subjects and respiratory patients. Clin. Sci. 68, 663–672 (1985).Google Scholar
  9. 9.
    R. B. Banzett, R. W. Lansing, M. B. Reld, L. Adams, and R. Brown, ‘Air hunger’ arising from increased PCO2 in mechanically ventilated quadriplegics. Respir. Physiol. 76, 53–67 (1989).CrossRefPubMedGoogle Scholar
  10. 10.
    T. Nishino, I. Tohru, S. Tomoko, and S. Jiro, Inhaled furosemide greatly alleviates the sensation of experimentally induced dyspnea. Am. J. Respir. Crit. Care Med. 161, 1963–1967 (2000).PubMedGoogle Scholar

Copyright information

© Kluwer Academic/Plenum Publishers, New York 2004

Authors and Affiliations

  • Yoshikazu Sakakibara
    • 1
  • Atsuko Masuda
    • 2
  • Toshio Kobayashi
    • 3
  • Shigeru Masuyama
    • 4
  • Yoshiyuki Honda
    • 4
  1. 1.Kanazawa Inst TechnolKanazawa
  2. 2.Tokyo Med & Dent UnivTokyoJapan
  3. 3.Hiroshima UnivHiroshima
  4. 4.Chiba UnivChiba

Personalised recommendations