Effect of Progressive Hypoxia with Moderate Hypercapnia on Ventilatory vs. Respiratory Sensation Responses in Humans

  • Yoshikazu Sakakibara
  • Atsuko Masuda
  • Toshio Kobayashi
  • Shigeru Masuyama
  • Yoshiyuki Honda
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 551)


Ventilatory response to CO2 combined with hypoxic stimulation has been well documented as exhibiting a positive interaction between the two stimuli in humans1, and in cats2,3. Furthermore, Mohan and Duffin4 examined the effect of hypoxia on ventilatory response to CO2 using a modified Read’s rebreathing method, covering wide range of CO2 including hypocapnic region following prior hyperventilation.


Visual Analog Scale Ventilatory Response Chemical Stimulus Hypoxic Ventilatory Response Respiratory Sensation 
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Copyright information

© Kluwer Academic/Plenum Publishers, New York 2004

Authors and Affiliations

  • Yoshikazu Sakakibara
    • 1
  • Atsuko Masuda
    • 2
  • Toshio Kobayashi
    • 3
  • Shigeru Masuyama
    • 4
  • Yoshiyuki Honda
    • 4
  1. 1.Kanazawa Inst TechnolKanazawa
  2. 2.Tokyo Med & Dent UnivTokyoJapan
  3. 3.Hiroshima UnivHiroshima
  4. 4.Chiba UnivChiba

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