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Effects of Pain and Audiovisual Stimulation on the Hypoxic Ventllatory Response

  • Suzanne B. Karan
  • J. Russell Norton
  • William Voter
  • Linda Palmer
  • Denham S. Ward
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 551)

Abstract

The non-chemoreflex drive to breathe is complex and influenced by the cortical, limbic and reticular activating systems. This reflex can be facilitatory or inhibitory and may have different modulating effects on normoxic ventilation and the acute hypoxic response (AHR). This interaction can be particularly important when considering the effects of the non-chemoreflex drive on anesthetic induced ventilatory depression.1, 2, 3, 4, 5 This study clarifies the effects of pain and audiovisual stimulation (AVS) on ventilation and on the AHR.

Keywords

Ventilatory Response Hypoxic Ventilatory Response Inspiratory Drive Audiovisual Stimulation Significant Test Effect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Sarton E, Dahan A, Teppema L, van den Elsen M, Olofsen E, Berkenbosch A, van Kleef J, Acute pain and central nervous system arousal do not restore impaired hypoxic ventilatory response during sevoflurane sedation, Anesthesiology, 85, 295–303 (1996)CrossRefPubMedGoogle Scholar
  2. 2.
    Lam AM, Clement JL, Knill RL, Surgical stimulation does not enhance ventilatory chemoreflexes during enflurane anaesthesia in man, Can. Anaesth. Soc. J., 27, 22–8 (1980)CrossRefPubMedGoogle Scholar
  3. 3.
    van den Elsen MJ, Dahan A, Berkenbosch A, DeGoede J, van Kleef JW, Olievier IC, Does subanesthetic isoflurane affect the ventilatory response to acute isocapnic hypoxia in healthy volunteers? Anesthesiology, 81, 860–7 (1994)CrossRefPubMedGoogle Scholar
  4. 4.
    Robotham JL, Do low-dose inhalational anesthetic agents alter ventilatory control? Anesthesiology, 80, 723–6 (1994)CrossRefPubMedGoogle Scholar
  5. 5.
    Pandit JJ, The variable effect of low-dose volatile anaesthetics on the acute ventilatory response to hypoxia in humans: a quantitative review, Anaesthesia 57(7), 632–43 (2002)CrossRefPubMedGoogle Scholar
  6. 6.
    Petersen KL, Rowbotham MC, A new human experimental pain model: the heat/capsaicin sensitization model, Neuroreport, 10, 1511–6 (1999)CrossRefPubMedGoogle Scholar
  7. 7.
    Dockery MP, Drummond GB, Respiratory response to skin incision during anaesthesia with infusions of propofol and alfentanil, Br. J. Anaesth., 88, 649–52 (2002)CrossRefPubMedGoogle Scholar
  8. 8.
    Gautier H, Control of the pattern of breathing, Clin.Sci. (Lond), 58, 343–8 (1980)PubMedGoogle Scholar
  9. 9.
    Borgbjerg FM, Nielsen K, Franks J, Experimental pain stimulates respiration and attenuates morphine-induced respiratory depression: a controlled study in human volunteers, Pain, 64, 123–8 (1996)CrossRefPubMedGoogle Scholar
  10. 10.
    Madej TH, Wheatley RG, Jackson IJ, Hunter D, Hypoxaemia and pain relief after lower abdominal surgery: comparison of extradural and patient-controlled analgesia, Br. J. Anaesth., 69, 554–7 (1992)CrossRefPubMedGoogle Scholar
  11. 11.
    Wheatley RG, Shepherd D, Jackson IJ, Madej TH, Hunter D, Hypoxaemia and pain relief after upper abdominal surgery: comparison of i.m. and patient-controlled analgesia, Br. J. Anaesth., 69, 558–61 (1992)CrossRefPubMedGoogle Scholar
  12. 12.
    Stone JG, Cozine KA, Wald A, Nocturnal oxygenation during patient-controlled analgesia, Anesth. Analg, 89, 104–10 (1999)CrossRefPubMedGoogle Scholar
  13. 13.
    Duranti R, Pantaleo T, Bellini F, Bongianni F, Scano G, Respiratory responses induced by the activation of somatic nociceptive afferents in humans, J. Appl. Physiol, 71, 2440–8 (1991)PubMedGoogle Scholar
  14. 14.
    Waldrop TG, Millhorn DE, Eldridge FL, Klingler LE, Respiratory responses to noxious and nonnoxious heating of skin in cats, J. Appl. Physiol, 57, 1738–41 (1984)PubMedGoogle Scholar
  15. 15.
    Spicuzza L, Gabutti A, Porta C, Montano N, Bernardi L, Yoga and chemoreflex response to hypoxia and hypercapnia, Lancet, 356, 1495–6 (2000)CrossRefPubMedGoogle Scholar
  16. 16.
    Chin K, Ohi M, Fukui M, Kita H, Tsuboi T, Hirata H, Noguchi T, Mishima M, Kuno K, Intellectual work using a video game inhibits post hyperventilation hyperpnoea following voluntary hyperventilation while it stimulates breathing at rest, in Modeling and Control of Ventilation, S. G. Semple, L. Adams, B. J. Whipp, eds., Plenum Press, New York, 1995, pp. 81–84Google Scholar
  17. 17.
    Mador MJ, Tobin MJ, Effect of alterations in mental activity on the breathing pattern in healthy subjects, Am. Rev. Respir. Dis., 144, 481–7 (1991)PubMedGoogle Scholar
  18. 18.
    Boiten FA, Frijda NH, Wientjes CJ, Emotions and respiratory patterns: review and critical analysis, Int. J. Psychophysiol., 17, 103–28 (1994)CrossRefPubMedGoogle Scholar
  19. 19.
    Tenney SM, Ou LC, Ventilatory response of decorticate and decerebrate cats to hypoxia and CO2, Respir. Physiol., 29, 81–92 (1977)CrossRefPubMedGoogle Scholar

Copyright information

© Kluwer Academic/Plenum Publishers, New York 2004

Authors and Affiliations

  • Suzanne B. Karan
    • 1
  • J. Russell Norton
    • 1
  • William Voter
    • 1
  • Linda Palmer
    • 1
  • Denham S. Ward
    • 1
  1. 1.Department of AnesthesiologyUniversity of Rochester School of Medicine and DentistryRochester

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