Respiratory, Cerebrovascular and Pressor Responses to Acute Hypoxia: Dependency on PetCo2

  • Philip N. Ainslie
  • Marc J. Poulin
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 551)


Acute hypoxia leads to changes not only in ventilation but also in cardiovascular1 and cerebral blood flow (CBF) dynamics2. However, there seems to be no available data concerning the combined ventilatory, cardiovascular and cerebrovascular responses to acute hypoxia in humans. Further, although hypercapnia may enhance the acute hypoxic ventilatory response (AHVR)3, it has not been clearly shown how hypercapnia may regulate changes in the cardiovascular and cerebrovascular responses to acute hypoxia. The lack of investigations surrounding the regulation and integration of the ventilatory, cerebrovascular and cardiovascular response by CO2 to acute hypoxia is somewhat surprising when one considers the important clinical relevance of such responses in health and disease.


Cerebral Blood Flow Cerebral Perfusion Pressure Mean Arterial Blood Pressure Muscle Sympathetic Nerve Activity Acute Hypoxia 
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Copyright information

© Kluwer Academic/Plenum Publishers, New York 2004

Authors and Affiliations

  • Philip N. Ainslie
    • 1
  • Marc J. Poulin
    • 1
    • 2
    • 3
  1. 1.Departments of Physiology & BiophysicsUniversity of CalgaryCalgaryCanada
  2. 2.Clinical Neurosciences, Faculty of MedicineCalgaryCanada
  3. 3.Faculty of KinesiologyUniversity of CalgaryCalgaryCanada

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