Advertisement

Respiratory, Cerebrovascular and Pressor Responses to Acute Hypoxia: Dependency on PetCo2

  • Philip N. Ainslie
  • Marc J. Poulin
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 551)

Abstract

Acute hypoxia leads to changes not only in ventilation but also in cardiovascular1 and cerebral blood flow (CBF) dynamics2. However, there seems to be no available data concerning the combined ventilatory, cardiovascular and cerebrovascular responses to acute hypoxia in humans. Further, although hypercapnia may enhance the acute hypoxic ventilatory response (AHVR)3, it has not been clearly shown how hypercapnia may regulate changes in the cardiovascular and cerebrovascular responses to acute hypoxia. The lack of investigations surrounding the regulation and integration of the ventilatory, cerebrovascular and cardiovascular response by CO2 to acute hypoxia is somewhat surprising when one considers the important clinical relevance of such responses in health and disease.

Keywords

Cerebral Blood Flow Cerebral Perfusion Pressure Mean Arterial Blood Pressure Muscle Sympathetic Nerve Activity Acute Hypoxia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    J.E. Brian, Carbon dioxide and the cerebral circulation, Anesthesiology 88, 1365–1386 (1998).CrossRefPubMedGoogle Scholar
  2. 2.
    R.S. Fitzgerald and S. Lahiri, Reflex responses to chemoreceptor stimulation, in: Handbook of Physiology, edited by A.P. Fishman. (American Physiological Society, Bethesda, Maryland, 1986), pp. 313–362.Google Scholar
  3. 3.
    A. Hanada, M. Sander and J. Gonzalez-Alonso, Human skeletal muscle sympathetic nerve activity, heart rate and limb haemodynamics with reduced blood oxygenation and exercise, J. Physiol. 551, 635–647 (2003).CrossRefPubMedGoogle Scholar
  4. 4.
    K. Ide, M. Eliasziw, and M.J. Poulin, The relationship between middle cerebral artery blood velocity and end-tidal Pco2 in the hypocapnic-hypercapnic range in humans, J. Appl. Physiol. 95, 129–137 (2003).PubMedGoogle Scholar
  5. 5.
    J.M. Marshall, Peripheral chemoreceptors and cardiovascular regulation, Physiol. Rev. 74, 543–594 (1994).PubMedGoogle Scholar
  6. 6.
    J.R. Munis and L.J. Lozada, Giraffes, siphons, and starling resistors. Cerebral perfusion pressure revisited, J. Neurosurg. Anesthesiol. 12, 290–296 (2000).CrossRefPubMedGoogle Scholar
  7. 7.
    M.J. Poulin and P.A. Robbins, Indexes of flow and cross-sectional area of the middle cerebral artery using doppler ultrasound during hypoxia and hypercapnia in humans, Stroke 27, 2244–2250 (1996).PubMedGoogle Scholar
  8. 8.
    M.J. Poulin and P.A. Robbins, Influence of cerebral blood flow on the ventilatory response to hypoxia in humans, Exp. Physiol. 83, 95–106 (1998).PubMedGoogle Scholar
  9. 9.
    J.W. Severinghaus, Cerebral circulation at high altitude, in: High Altitude: An Exploration of Human Adaptation, edited by T.F. Hornbein and R.B. Schoene. (Marcel Dekker, New York, 2001), pp. 343–375.Google Scholar
  10. 10.
    J.W. Severinghaus, Simple, accurate equations for human blood O2 dissociation computations, J. Appl. Physiol. 46, 599–602 (1979).PubMedGoogle Scholar
  11. 11.
    S. Shimojyo, P. Scheinberg, K. Kogure, and O.M. Reinmuth, The effects of graded hypoxia upon transient cerebral blood flow and oxygen consumption, Neurology 18, 127–133 (1968).PubMedGoogle Scholar
  12. 12.
    A. Weyland, W. Buhre, S. Grund, H. Ludwig, S. Kazmaier, W. Weyland, and H. Sonntag, Cerebrovascular tone rather than intracranial pressure determines the effective downstream pressure of the cerebral circulation in the absence of intracranial hypertension. J. Neurosurg. Anesthesiol. 12, 210–216 (2000).CrossRefPubMedGoogle Scholar
  13. 13.
    A. Xie, J.B. Skatrud, D.C. Crabtree, D.S. Puleo, B.M. Goodman, and B.J. Morgan, Neurocirculatory consequences of intermittent asphyxia in humans, J. Appl. Physiol. 89, 1333–1339 (2000).PubMedGoogle Scholar

Copyright information

© Kluwer Academic/Plenum Publishers, New York 2004

Authors and Affiliations

  • Philip N. Ainslie
    • 1
  • Marc J. Poulin
    • 1
    • 2
    • 3
  1. 1.Departments of Physiology & BiophysicsUniversity of CalgaryCalgaryCanada
  2. 2.Clinical Neurosciences, Faculty of MedicineCalgaryCanada
  3. 3.Faculty of KinesiologyUniversity of CalgaryCalgaryCanada

Personalised recommendations