Respiratory, Cerebrovascular and Pressor Responses to Acute Hypoxia: Dependency on PetCo2
- 390 Downloads
Acute hypoxia leads to changes not only in ventilation but also in cardiovascular1 and cerebral blood flow (CBF) dynamics2. However, there seems to be no available data concerning the combined ventilatory, cardiovascular and cerebrovascular responses to acute hypoxia in humans. Further, although hypercapnia may enhance the acute hypoxic ventilatory response (AHVR)3, it has not been clearly shown how hypercapnia may regulate changes in the cardiovascular and cerebrovascular responses to acute hypoxia. The lack of investigations surrounding the regulation and integration of the ventilatory, cerebrovascular and cardiovascular response by CO2 to acute hypoxia is somewhat surprising when one considers the important clinical relevance of such responses in health and disease.
KeywordsCerebral Blood Flow Cerebral Perfusion Pressure Mean Arterial Blood Pressure Muscle Sympathetic Nerve Activity Acute Hypoxia
Unable to display preview. Download preview PDF.
- 2.R.S. Fitzgerald and S. Lahiri, Reflex responses to chemoreceptor stimulation, in: Handbook of Physiology, edited by A.P. Fishman. (American Physiological Society, Bethesda, Maryland, 1986), pp. 313–362.Google Scholar
- 9.J.W. Severinghaus, Cerebral circulation at high altitude, in: High Altitude: An Exploration of Human Adaptation, edited by T.F. Hornbein and R.B. Schoene. (Marcel Dekker, New York, 2001), pp. 343–375.Google Scholar
- 12.A. Weyland, W. Buhre, S. Grund, H. Ludwig, S. Kazmaier, W. Weyland, and H. Sonntag, Cerebrovascular tone rather than intracranial pressure determines the effective downstream pressure of the cerebral circulation in the absence of intracranial hypertension. J. Neurosurg. Anesthesiol. 12, 210–216 (2000).CrossRefPubMedGoogle Scholar