Antioxidants Prevent Blunting of Hypoxic Ventilatory Response by Low-Dose Halothane

  • Albert Dahan
  • Raymonda Romberg
  • Elise Sarton
  • Luc Teppema
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 551)


In adult humans, acute isocapnic hypoxia induces a brisk ventilatory response. This acute hypoxic response or AHR originates at the peripheral chemoreceptors of the carotid bodies.1,2 The full mechanisms of oxygen sensing at the carotid bodies (CB) is still poorly understood. At present it is thought that membrane ion channels (e.g. potassium channels) are critically involved and that low oxygen inhibits various K+-currents through the CB type I cell membrane (see reference #3 and references cited therein). This causes membrane depolarization and consequently the influx of calcium ions into the cell and the activation of a complex cascade of events within the type I cell. At the end of this cascade, the cell releases neurotransmitters (e.g., acetylcholine and ATP) which activate postsynaptic receptors located on afferent endings of the carotid sinus nerve.


Carotid Body Ventilatory Response Minimum Alveolar Concentration Glomus Cell Peripheral Chemoreceptor 
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Copyright information

© Kluwer Academic/Plenum Publishers, New York 2004

Authors and Affiliations

  • Albert Dahan
    • 1
  • Raymonda Romberg
    • 1
  • Elise Sarton
    • 1
  • Luc Teppema
    • 1
  1. 1.Department of AnesthesiologyLeiden University Medical CenterLeidenThe Netherlands

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