Stability Analysis of the Respiratory Control System During Sleep
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Chemoreflex control of breathing during sleep consists of two negative feedback loops with delays depending on the controlled variables (PaCO 2 and PaO 2). The peripheral chemoreceptor (PCR) loop operates with short delay and the central chemoreceptor (CCR) loop operates with long delay (see Figure 1). Periodic breathing, indicative of instability in the control system, is commonly seen during sleep in premature infants, in patients with heart failure, and during exposure to high altitude. These periodicities appear to relate to the operation of the two chemoreflex loops.
KeywordsCerebral Blood Flow Negative Feedback Loop Ventilatory Response Central Sleep Apnea Congestive Heart Failure Patient
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