Abstract
Chemoreflex control of breathing during sleep consists of two negative feedback loops with delays depending on the controlled variables (PaCO 2 and PaO 2). The peripheral chemoreceptor (PCR) loop operates with short delay and the central chemoreceptor (CCR) loop operates with long delay (see Figure 1). Periodic breathing, indicative of instability in the control system, is commonly seen during sleep in premature infants, in patients with heart failure, and during exposure to high altitude. These periodicities appear to relate to the operation of the two chemoreflex loops.
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© 2004 Kluwer Academic/Plenum Publishers, New York
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Topor, Z.L., Vasilakos, K., Remmers, J.E. (2004). Stability Analysis of the Respiratory Control System During Sleep. In: Champagnat, J., Denavit-Saubié, M., Fortin, G., Foutz, A.S., Thoby-Brisson, M. (eds) Post-Genomic Perspectives in Modeling and Control of Breathing. Advances in Experimental Medicine and Biology, vol 551. Springer, Boston, MA. https://doi.org/10.1007/0-387-27023-X_31
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DOI: https://doi.org/10.1007/0-387-27023-X_31
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