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Immediate Effects of Bilateral Carotid Body Resection on Total Respiratory Resistance and Compliance in Humans

  • Benjamin Winter
  • Brian J. Whipp
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 551)

Abstract

In 1962, Nadel and Widdicombe1 conclusively demonstrated a reflex increase in airways resistance (Raw) in response to carotid body stimulation in the dog. This effect could be eliminated by blocking either the glossopharyngeal or vagus nerves, i.e. the afferent or efferent limbs of the reflex respectively. That the peripheral chemoreceptors not only act reflexly on respiration but also cause reflex bronchoconstriction was also stressed by Widdicombe2 in his review of “Chemoreceptor Control of the Airways.” This is among the reasons often cited as a basis for potential benefits that might accrue from bilateral carotid body resection (BCBR) in patients with severe chronic obstructive pulmonary disease (COPD).3

Keywords

Chronic Obstructive Pulmonary Disease Chronic Obstructive Pulmonary Disease Patient Carotid Body Severe Chronic Obstructive Pulmonary Disease Total Lung Capacity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic/Plenum Publishers, New York 2004

Authors and Affiliations

  • Benjamin Winter
    • 1
  • Brian J. Whipp
    • 2
  1. 1.Garfield HospitalMonterey Park
  2. 2.Department of PhysiologySt George’s Hospital Medical SchoolLondonUK

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