Respiratory Role of Ionotropic Glutamate Receptors in the Rostral Ventral Respiratory Group of the Rabbit
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Neuronal mechanisms responsible for generating the eupneic pattern of breathing are localized within the pons and the medulla oblongata.1, 2, 3 Excitatory amino acids (EAAs) are known to be involved in the generation of rhythmic respiratory drive in mammals; both N-methyl-D-aspartic acid (NMDA) and non-NMDA receptors are present within the medullary respiratory neuronal aggregates, and in particular in the ventral respiratory group (VRG).2,4 Recently, we have provided evidence5 that EAA-mediated neurotransmission controls the intensity of eupneic inspiratory activity within the intermediate, almost purely inspiratory VRG (iVRG) mainly through NMDA receptors, whilst it does not appear to have a significant role in shaping the pattern of breathing at the level of caudal VRG.
KeywordsNMDA Receptor Kainic Acid Ionotropic Glutamate Receptor Respiratory Response Respiratory Rhythm
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- 8.D. Mutolo, F. Bongianni, M. Carfi, and T. Pantaleo, Respiratory changes induced by kainic acid lesions in rostral ventral respiratory group of rabbits, Am. J. Physiol. (Regul. Integr. Comp Physiol.) 283, R227–R242 (2002).Google Scholar
- 11.J. W. Shek, G. Y. Wen, and H. M. Wisniewski. Atlas of the Rabbit Brain and Spinal Cord. Karger, Basel, 1986.Google Scholar
- 17.D. W. Richter, D. Ballantyne, and J. E. Remmers, How is the respiratory rhythm generated? A model, News Physiol. Sci. 1, 109–112 (1986).Google Scholar