Respiratory Role of Ionotropic Glutamate Receptors in the Rostral Ventral Respiratory Group of the Rabbit
Neuronal mechanisms responsible for generating the eupneic pattern of breathing are localized within the pons and the medulla oblongata.1, 2, 3 Excitatory amino acids (EAAs) are known to be involved in the generation of rhythmic respiratory drive in mammals; both N-methyl-D-aspartic acid (NMDA) and non-NMDA receptors are present within the medullary respiratory neuronal aggregates, and in particular in the ventral respiratory group (VRG).2,4 Recently, we have provided evidence5 that EAA-mediated neurotransmission controls the intensity of eupneic inspiratory activity within the intermediate, almost purely inspiratory VRG (iVRG) mainly through NMDA receptors, whilst it does not appear to have a significant role in shaping the pattern of breathing at the level of caudal VRG.
KeywordsNMDA Receptor Kainic Acid Ionotropic Glutamate Receptor Respiratory Response Respiratory Rhythm
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