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In-Silico Model of NMDA and Non-NMDA Receptor Activities Using Analog Very-Large-Scale Integrated Circuits

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Post-Genomic Perspectives in Modeling and Control of Breathing

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 551))

Abstract

Computational modeling is a useful analytical tool that (with valid data) may help to explain how complex brain systems work. In respiratory control, various neural network models have been proposed to explore the possible mechanisms of respiratory rhythmogenesis based on intrinsic neuronal properties as well as interactions at the network level1,2. However, the large parameter space that must be tested for such neuromorphic models makes it rather cumbersome and time consuming to simulate even a modest size network with discrete respiratory neurons. For large-scale neural network models involving multiple populations of respiratory neurons, such simulations become computationally prohibitive on general-purpose digital computers.

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References

  1. Rybak, I.A., Shevtsova, N.A., St-John, W.M., Paton, J.F.R., Pierrefiche, O. Endogenous rhythm generation in the pre-Botzinger complex and ionic currents: modeling and in vitro studies, European Journal of Neuroscience 18(2): 239–257 (2003).

    Article  PubMed  Google Scholar 

  2. Butera, R.J., Johnson, S.M., DelNegro, C.A., Rinzel, J., Smith, J.C. Dynamics of excitatory networks of bursting pacemaking neurons: Modeling and experimental studies of the respiratory central pattern generator. Neurocomputing: 32: 323–330 (2000).

    Article  Google Scholar 

  3. Poon, C.-S. and M. Siniaia. Plasticity of cardiorespiratory neural processing: classification and computational functions. Respirat. Physiol. Special Issue on Modeling and Control of Breathing 122: 83–109 (2000).

    Article  CAS  Google Scholar 

  4. Mead., C. Analog VLSI and Neural Systems. 1989. Addison-Wesley. Reading Massachusetts.

    Google Scholar 

  5. Mahowald, M. and R. Douglas, A Silicon neuron. Nature 354: pp. 515–518, (1991).

    Article  CAS  PubMed  Google Scholar 

  6. Hebb, D. The Organization of Behavior. 1949, New York Wiely.

    Google Scholar 

  7. Young, D., and C.S. Poon. A Hebbian feedback covariance learning paradigm for self-tuning optimal control. IEEE Tran Systems and Cybernetics 31: 173–186 (2001).

    Article  CAS  Google Scholar 

  8. Rachmuth, G. and C.S. Poon. Design of a neuromorphic hebbian synapse using analog VLSI. First International IEEE EMBS Conference on Neural Engineering, Capri, Italy, 20–22 March 2003 Conference Proceedings., pp. 221–224 (2003).

    Google Scholar 

  9. Mussa-Ivalidi, F.A., and Miller, L.E. Brain-Machine interfaces: computational demands and clinical needs meet basic neuroscience. Trends in Neuroscience. 26: 329–334 (2003).

    Article  Google Scholar 

  10. Jung, R., Brauer, E.J., Abbas, J.J. Real-time interaction between a neuromorphic electronic circuit and the spinal cord. IEEE Transactions on Neural Systems and Rehabilitation Engineering. 9: 319–326 (2001).

    Article  CAS  PubMed  Google Scholar 

  11. Krebs, H. Hogan, N., Aisen, M.L., and Volpe, T. Robot-aided neurorehabilitation. IEEE Trans Rehabil Engineering, 6: 75–87 (1998).

    Article  CAS  Google Scholar 

  12. Sutton, R.S., and Barto, A.G. Reinforcement Learning. (1998). Cambridge, Massachusetts, MIT Press.

    Google Scholar 

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© 2004 Kluwer Academic/Plenum Publishers, New York

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Rachmuth, G., Poon, CS. (2004). In-Silico Model of NMDA and Non-NMDA Receptor Activities Using Analog Very-Large-Scale Integrated Circuits. In: Champagnat, J., Denavit-Saubié, M., Fortin, G., Foutz, A.S., Thoby-Brisson, M. (eds) Post-Genomic Perspectives in Modeling and Control of Breathing. Advances in Experimental Medicine and Biology, vol 551. Springer, Boston, MA. https://doi.org/10.1007/0-387-27023-X_26

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