Breathing at Birth: Influence of Early Developmental Events
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Respiration is a rhythmic motor behavior that appears in the fetus and acquires a vital importance at birth. It is generated centrally, within neuronal networks of the brainstem. Recently, examination of hindbrain activities in the embryo has revealed that a central rhythm generator is active in the brainstem before fetal maturation and conforms to the segmented organization of the embryonic hindbrain at this stage of development. From physiological studies of this primordial rhythm generator in embryos, we may therefore gain an understanding of how genes govern development of neuronal networks and specify patterns of motor activities operating throughout life.
KeywordsNeuronal Network Respiratory Rhythm Rhythm Generation GABAergic Inhibition Respiratory Rhythm Generation
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