Modulation of Inspiratory Inhibition of the Bötzinger Complex by Raphe Pallidus and Locus Coeruleus in Rabbits
In mammals, the respiratory rhythm is generated by the brainstem neuronal network. The Bötzinger complex (Böt.C) is a group of inhibitory expiratory neurons at the rostral end of the ventral respiratory group (VRG) near the retrofacial nucleus. Neurons in the Böt.C have widespread inhibitory connections with other medullary respiratory neurons and phrenic motoneurons.1,2 Long train stimulation of the Böt.C caused inhibition of inspiration and inspiratory to expiratory phase-switching.3,4
KeywordsGABAa Receptor Locus Coeruleus Respiratory Rhythm Ventral Respiratory Group Phrenic Motoneuron
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