BDNF Preferentially Targets Membrane Properties of Rhythmically Active Neurons in the pre-Bötzinger Complex in Neonatal Mice

  • Muriel Thoby-Brisson
  • Sandra Autran
  • Gilles Fortin
  • Jean Champagnat
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 551)


Neurotrophins are a class of factors known to be involved in the development, maintenance, plasticity and survival of the peripheral and central nervous systems1. Neurotrophins are active through high-affinity receptors having an intrinsic tyrosine-kinase activity2,3. One of these neurotrophins, the brain-derived neurotrophic factor (BDNF) has been shown to be involved in a wide range of developmental and plasticity mechanisms and its biological action depends mainly upon activation of the TrkB receptor sub-type and to a less extent to the p75 receptors. BDNF binding on TrkB receptors initiates a cascade of events of phosphorylation that activate a complex of signal proteins and the induction of several genes4.


Membrane Property Respiratory Rhythm Respiratory Rhythm Generation Rhythmic Neuron BDNF Application 
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Copyright information

© Kluwer Academic/Plenum Publishers, New York 2004

Authors and Affiliations

  • Muriel Thoby-Brisson
    • 1
  • Sandra Autran
    • 1
  • Gilles Fortin
    • 1
  • Jean Champagnat
    • 1
  1. 1.Neurobiologie Génétique et Intégrative—Institut de Neurobiologie A. FessardCNRSGif sur YvetteFrance

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