BDNF Preferentially Targets Membrane Properties of Rhythmically Active Neurons in the pre-Bötzinger Complex in Neonatal Mice
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Neurotrophins are a class of factors known to be involved in the development, maintenance, plasticity and survival of the peripheral and central nervous systems1. Neurotrophins are active through high-affinity receptors having an intrinsic tyrosine-kinase activity2,3. One of these neurotrophins, the brain-derived neurotrophic factor (BDNF) has been shown to be involved in a wide range of developmental and plasticity mechanisms and its biological action depends mainly upon activation of the TrkB receptor sub-type and to a less extent to the p75 receptors. BDNF binding on TrkB receptors initiates a cascade of events of phosphorylation that activate a complex of signal proteins and the induction of several genes4.
KeywordsMembrane Property Respiratory Rhythm Respiratory Rhythm Generation Rhythmic Neuron BDNF Application
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- 5.J. T. Erickson, J. C. Conover, V. Borday, J. Champagnat, M. Barbacid, G. Yancopoulos and D. M. Katz, Mice lacking brain-derived neurotrophic factor exhibit visceral sensory neuron losses distinct from mice lacking NT4 and display a severe developmental deficit in control of breathing, J. Neurosci. 16, 5361–5371 (1996).PubMedGoogle Scholar
- 9.J. M. Ramirez, U. J. A. Quellmalz and D. W. Richter, Postnatal changes in the mammalian respiratory network as revealed by the transverse brainstem slice preparation of mice, J. Physiol. (London). 491, 799–812. (1996).Google Scholar