BDNF Preferentially Targets Membrane Properties of Rhythmically Active Neurons in the pre-Bötzinger Complex in Neonatal Mice
Neurotrophins are a class of factors known to be involved in the development, maintenance, plasticity and survival of the peripheral and central nervous systems1. Neurotrophins are active through high-affinity receptors having an intrinsic tyrosine-kinase activity2,3. One of these neurotrophins, the brain-derived neurotrophic factor (BDNF) has been shown to be involved in a wide range of developmental and plasticity mechanisms and its biological action depends mainly upon activation of the TrkB receptor sub-type and to a less extent to the p75 receptors. BDNF binding on TrkB receptors initiates a cascade of events of phosphorylation that activate a complex of signal proteins and the induction of several genes4.
KeywordsMembrane Property Respiratory Rhythm Respiratory Rhythm Generation Rhythmic Neuron BDNF Application
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