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Converging Functional and Anatomical Evidence for Novel Brainstem Respiratory Compartments in the Rat

  • Donald R. McCrimmon
  • George F. Alheid
  • Minchun Jiang
  • Tara Calandriello
  • Anupama Topgi
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 551)

Abstract

Central nervous system circuits controlling respiratory motoneurons have usually been divided into a dorsal medullary respiratory group—associated with portions of the nucleus of the solitary tract, a ventrolateral medullary respiratory group—mostly ventral to the motoneurons of nucleus ambiguus, and a pontine respiratory group—associated with portions of the parabrachial nuclear complex. When visualized via retrograde labeling of neurons from injections within the ventrolateral medulla (Fig. 1 A), the labeled aggregates of respiratory-related neurons in the pons and medulla appear to form a practically continuous column of cells. These are concentrated in lateral brainstem areas stretching from the caudal mesencephalon, through the pons and medulla14. This pattern of labeling highlights the rostrocaudal columnar organization of respiratory neurons that integrates respiratory control across the entire extent of the rhombencephalon. A second organizational theme is represented by a rostrocaudal segmentation of respiratory neurons within this column into functional compartments (Fig. 1B).

Keywords

Respiratory Rhythm Ventrolateral Medulla Retrograde Label Nucleus Ambiguus Respiratory Neuron 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic/Plenum Publishers, New York 2004

Authors and Affiliations

  • Donald R. McCrimmon
    • 1
  • George F. Alheid
    • 2
  • Minchun Jiang
    • 2
  • Tara Calandriello
    • 2
  • Anupama Topgi
    • 2
  1. 1.Dept. Physiology-M211Northwestern University Feinberg School of MedicineChicagoUSA
  2. 2.Northwestern University Feinberg School of MedicineChicagoUSA

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