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Selective Alteration of the Ventilatory Response to Hypoxia Results from Mutation in the Myelin Proteolipid Protein Gene

  • Martha J. Miller
  • Musa A. Haxhiu
  • Cindy D. Kangas
  • Paraskevi Georgiadis
  • Tatyana I. Gudz
  • Wendy B. Macklin
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 551)

Abstract

Central nervous system myelin is formed from the lipid-rich, highly specialized oligoden-drocyte plasma membrane, which ensheaths axons, leaving spaces only at the nodes of Ranvier. Within the myelin sheath are many myelin-associated lipophilic proteins, the most abundant of which are myelin proteolipid protein (PLP) and myelin basic protein (MBP). These two proteins constitute 60–90% of myelin protein in mammalian species.1

Keywords

Myelin Basic Protein Ventilatory Response Proteolipid Protein Hypoglossal Nucleus Hypoxic Ventilatory Response 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic/Plenum Publishers, New York 2004

Authors and Affiliations

  • Martha J. Miller
    • 1
  • Musa A. Haxhiu
    • 2
  • Cindy D. Kangas
    • 3
  • Paraskevi Georgiadis
    • 1
  • Tatyana I. Gudz
    • 3
  • Wendy B. Macklin
    • 3
  1. 1.Dept. PediatricsCase Western Reserve UniversityCleveland
  2. 2.Dept. Physiol and BiophysHoward UniversityWashington, D.C.
  3. 3.Dept. Neurosci., Lerner Research Inst.Cleveland Clinic FoundationCleve.

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