Selective Alteration of the Ventilatory Response to Hypoxia Results from Mutation in the Myelin Proteolipid Protein Gene

  • Martha J. Miller
  • Musa A. Haxhiu
  • Cindy D. Kangas
  • Paraskevi Georgiadis
  • Tatyana I. Gudz
  • Wendy B. Macklin
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 551)


Central nervous system myelin is formed from the lipid-rich, highly specialized oligoden-drocyte plasma membrane, which ensheaths axons, leaving spaces only at the nodes of Ranvier. Within the myelin sheath are many myelin-associated lipophilic proteins, the most abundant of which are myelin proteolipid protein (PLP) and myelin basic protein (MBP). These two proteins constitute 60–90% of myelin protein in mammalian species.1


Myelin Basic Protein Ventilatory Response Proteolipid Protein Hypoglossal Nucleus Hypoxic Ventilatory Response 
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Copyright information

© Kluwer Academic/Plenum Publishers, New York 2004

Authors and Affiliations

  • Martha J. Miller
    • 1
  • Musa A. Haxhiu
    • 2
  • Cindy D. Kangas
    • 3
  • Paraskevi Georgiadis
    • 1
  • Tatyana I. Gudz
    • 3
  • Wendy B. Macklin
    • 3
  1. 1.Dept. PediatricsCase Western Reserve UniversityCleveland
  2. 2.Dept. Physiol and BiophysHoward UniversityWashington, D.C.
  3. 3.Dept. Neurosci., Lerner Research Inst.Cleveland Clinic FoundationCleve.

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