Selective Alteration of the Ventilatory Response to Hypoxia Results from Mutation in the Myelin Proteolipid Protein Gene
Central nervous system myelin is formed from the lipid-rich, highly specialized oligoden-drocyte plasma membrane, which ensheaths axons, leaving spaces only at the nodes of Ranvier. Within the myelin sheath are many myelin-associated lipophilic proteins, the most abundant of which are myelin proteolipid protein (PLP) and myelin basic protein (MBP). These two proteins constitute 60–90% of myelin protein in mammalian species.1
KeywordsMyelin Basic Protein Ventilatory Response Proteolipid Protein Hypoglossal Nucleus Hypoxic Ventilatory Response
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