A SIDS-Like Phenotype is Associated With Reduced Respiratory Chemoresponses in PACAP Deficient Neonatal Mice
Pituitary adenylate cyclase-activating polypeptide (PACAP) is an abundant neuropep-tide within the CNS1. Mice deficient in PACAP or the PACAP-preferring receptor (PAC1), though normal at birth, are more susceptible than littermates to death during the neonatal period2,3, with death sometimes occurring suddenly4. The reason why PACAP signaling increases the chance of surviving the neonatal period is unknown, but previous studies have indicated it is important for a proper physiological response to hypothermia5.
KeywordsNeonatal Mortality Sudden Infant Death Syndrome Case Fatty Acid Oxidation Disorder Sudden Infant Death Syndrome Victim Dorsal Vagal Nucleus
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