A SIDS-Like Phenotype is Associated With Reduced Respiratory Chemoresponses in PACAP Deficient Neonatal Mice
- 403 Downloads
Pituitary adenylate cyclase-activating polypeptide (PACAP) is an abundant neuropep-tide within the CNS1. Mice deficient in PACAP or the PACAP-preferring receptor (PAC1), though normal at birth, are more susceptible than littermates to death during the neonatal period2,3, with death sometimes occurring suddenly4. The reason why PACAP signaling increases the chance of surviving the neonatal period is unknown, but previous studies have indicated it is important for a proper physiological response to hypothermia5.
KeywordsNeonatal Mortality Sudden Infant Death Syndrome Case Fatty Acid Oxidation Disorder Sudden Infant Death Syndrome Victim Dorsal Vagal Nucleus
Unable to display preview. Download preview PDF.
- 2.H. Hashimoto, N. Shintani, K. Tanaka, W. Mori, M. Hirose, T. Matsuda, M. Sakaue, J. Miyazaki, H. Niwa, F. Tashiro, K. Yamamoto, K. Koga, S. Tomimoto, A. Kunugi, S. Suetake, and A. Baba, Altered psychomotor behaviors in mice lacking pituitary adenylate cyclase-activating polypeptide (PACAP), Proc Natl Acad Sci USA 98(23) 13355–60 (2001).CrossRefPubMedGoogle Scholar
- 3.C. Hamelink, O. Tjurmina, R. Damadzic, W.S. Young, E. Weihe, H.W. Lee, and L.E. Eiden, Pituitary adenylate cyclase-activating polypeptide is a sympathoadrenal neurotransmitter involved in catecholamine regulation and glucohomeostasis, Proc Natl Acad Sci USA 99(1) 461–6 (2002).CrossRefPubMedGoogle Scholar
- 4.S.L. Gray, K.J. Cummings, F.R. Jirik, and N.M. Sherwood, Targeted disruption of the pituitary adenylate cyclase-activating polypeptide gene results in early postnatal death associated with dysfunction of lipid and carbohydrate metabolism, Mol Endocrinol 15(10) 1739–47 (2001).CrossRefPubMedGoogle Scholar
- 6.K.J. Cummings, J.D. Pendlebury, N.M. Sherwood and R.J.A. Wilson, Sudden neonatal death in PACAP deficient mice is associated with reduced respiratory chemoresponse and susceptibility to apnea, J. Physiol: in press.Google Scholar
- 11.C.E. Hunt, Abnormal hypercarbic and hypoxic sleep arousal responses in Near-Miss SIDS infants, PediatrRes 15(11) 1462–4 (1981).Google Scholar
- 18.R.G. Boles, E.A. Buck, M.G. Blitzer, M.S. Platt, T.M. Cowan, S.K. Martin, H. Yoon, J.A. Madsen, M. Reyes-Mugica, and P. Rinaldo, Retrospective biochemical screening of fatty acid oxidation disorders in postmortem livers of 418 cases of sudden death in the first year of life, J Pediatr 132(6) 924–33 (1998).CrossRefPubMedGoogle Scholar