Different Profile in Ventilatory vs. Respiratory Sensation Responses to CO2 with Varying Po2

  • Atsuko Masuda
  • Yoshikazu Sakakibara
  • Toshio Kobayashi
  • Michiko Tanaka
  • Yoshiyuki Honda
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 551)


Recently, we1 reported that the slope of the respiratory sensation response curve to CO2 assessed by visual analog scale (VAS), exhibited a parallel leftward shift when combined with hypoxic stimulation. However, further analysis additionally elucidated the presence of significant upward shift of this VAS response curve in the same experimental condition. On the other hand, the CO2-ventilation response curve increased its slope with increasing hypoxic stimulation, and the extrapolated response lines converged at the horizontal axis known as the so-called Oxford fan2. These contrasting change between ventilatory vs. VAS response curves led us to certain speculations and assumptions about the different control mechanisms and anatomical regions possibly responsible for our experimental findings.


Visual Analog Scale Carotid Body Ventilatory Response Corollary Discharge Respiratory Sensation 
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Copyright information

© Kluwer Academic/Plenum Publishers, New York 2004

Authors and Affiliations

  • Atsuko Masuda
    • 1
  • Yoshikazu Sakakibara
    • 2
  • Toshio Kobayashi
    • 3
  • Michiko Tanaka
    • 4
  • Yoshiyuki Honda
    • 5
  1. 1.Tokyo Med & Dent UnivTokyoJapan
  2. 2.Kanazawa Inst TechnolKanazawa
  3. 3.Hiroshima UnivHiroshima
  4. 4.Miyazaki Pref Nurs UnivMiyazaki
  5. 5.Chiba UnivChiba

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