Different Profile in Ventilatory vs. Respiratory Sensation Responses to CO2 with Varying Po2
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Recently, we1 reported that the slope of the respiratory sensation response curve to CO2 assessed by visual analog scale (VAS), exhibited a parallel leftward shift when combined with hypoxic stimulation. However, further analysis additionally elucidated the presence of significant upward shift of this VAS response curve in the same experimental condition. On the other hand, the CO2-ventilation response curve increased its slope with increasing hypoxic stimulation, and the extrapolated response lines converged at the horizontal axis known as the so-called Oxford fan2. These contrasting change between ventilatory vs. VAS response curves led us to certain speculations and assumptions about the different control mechanisms and anatomical regions possibly responsible for our experimental findings.
KeywordsVisual Analog Scale Carotid Body Ventilatory Response Corollary Discharge Respiratory Sensation
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- 2.D.J.C. Cunningham, P.A. Robbins, and C.B. Wolff, Interaction of respiratory responses to changes in alveolar partial pressure of CO2 and O2 in arterial pH, in: Handbook of Physiology, Sec 3, The respiratory System Vol., Control of breathing, Part 2, Bethesda, MD, edited by A.P. Fishman, N. S. Cherniack, J. D. Widdicombe, and S. T. Geiger (Am. Physiol. Soc, Berthesda, MD, 1986) pp. 475–528.Google Scholar
- 4.D.I. McClosky, Corollary discharges: motor commands and perception, in: Handbook of Physiology. The nervous system. Sec 1, Vol 2, part 2, edited by J. K. Brookhart, V.B. Mountcatsle (Am. Physiol. Soc, Berthesda, MD, 1981), pp. 1415–1447.Google Scholar