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The Biogenesis and Cell Biology of Peroxisomes in Human Health and Disease

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The Biogenesis of Cellular Organelles

Part of the book series: Molecular Biology Intelligence Unit ((MBIU))

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Abstract

Recent results have demonstrated that the molecular mechanisms of peroxisomal membrane biogenesis and the post-translational import of proteins into the organelle do not follow those paradigms established for other subcellular organelles. As such, we have much to learn about the peroxisome, and the human diseases that occur as a result of its malfunction. In this review, we describe how peroxisomes arise through these seemingly non-conventional processes, specifically focusing on how the organelle membrane assembles its constituent proteins, and how appropriate enzymes are imported. Particular emphasis is placed on identifying the role of specific peroxins at each step in the biosynthetic mechanism.

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Authors and Affiliations

  1. Department of Pharmacology, Wayne State University School of Medicine, Detroit, Michigan, USA

    Stanley R. Terlecky Ph.D.

  2. Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada

    Paul A. Walton Ph.D.

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  1. Stanley R. Terlecky Ph.D.
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Terlecky, S.R., Walton, P.A. (2005). The Biogenesis and Cell Biology of Peroxisomes in Human Health and Disease. In: The Biogenesis of Cellular Organelles. Molecular Biology Intelligence Unit. Springer, Boston, MA. https://doi.org/10.1007/0-387-26867-7_9

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