Focussing on Genomic and Phenomic Correlations in Respiration of Non-Melanotic Skin Cancers

  • David J. Maguire
  • Nicholas A. Lintell
  • Michael McCabe
  • L. Griffiths
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 566)


In recent years, with the development of techniques in modern molecular biology, it has become possible to study the genetic basis of carcinogenesis down to the level of DNA sequence. Major advances have been made in our understanding of the genes involved in cell cycle control and descriptions of mutations in those genes. These developments have led to the definition of the role of specific oncogenes and tumour suppressor genes in several cancers, including, for example, colon cancers and some forms of breast cancer. Work reported from our laboratory has led to the identification of a number of candidate genes involved in the development of non-melanotic skin cancers. In this chapter, we attempt to further explain the observed (phenomic) alterations in metabolic pathways associated with oxygen consumption with the changes at the genetic level.


Gene Pair Basal Cell Carcinoma Comparative Genomic Hybridisation Specific Exon Solar Keratosis 
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Copyright information

© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  • David J. Maguire
  • Nicholas A. Lintell
  • Michael McCabe
  • L. Griffiths

There are no affiliations available

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